| 2024-10-29 |
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration |
Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press. |
 |
| 2024-07-17 |
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia |
Cell Chemical Biology. 2024 Jul 17;Article in Press. |
|
| 2024-06-01 |
Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus |
Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779. |
|
| 2024-02-16 |
Postfermented tea extract potently alleviates glucose metabolism disorders in vitro and in vivo |
ACS Food Science and Technology. 2024 Feb 16;4(2):479-490. |
|
| 2023-07-20 |
Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin |
Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688. |
|
| 2023-02-07 |
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588. |
|
| 2023-01-19 |
The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b [Erratum:Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.] |
Pharmaceutics. 2023 Jan 19;15(2):Article number 342. |
|
| 2022-12-05 |
Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation |
European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728. |
|
| 2022-12-02 |
Omicron-specific mRNA vaccine induced cross-protective immunity against ancestral SARS-CoV-2 infection with low neutralizing antibodies |
Journal of Medical Virology. 2022 Dec 2;95:Article number e28370. |
|
| 2022-11-15 |
BPR0C261, an analogous of microtubule disrupting agent D-24851 enhances the radiosensitivity of human non-small cell lung cancer cells via p53-dependent and p53-independent pathways |
International Journal of Molecular Sciences. 2022 Nov 15;23(22):Article number 14083. |
|
| 2022-11-01 |
Peritoneal effluent MicroRNA profile for detection of encapsulating peritoneal sclerosis |
Clinica Chimica Acta. 2022 Nov 1;536:45-55. |
|
| 2022-11 |
Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone |
Bioorganic Chemistry. 2022 Nov;128:Article number 105905. |
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| 2022-10-13 |
Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate |
Journal of Medicinal Chemistry. 2022 Oct 13;65(19):12802-12824. |
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| 2022-10-03 |
Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention |
International Journal of Molecular Sciences. 2022 Oct 3;23(19):Article number 11730. |
|
| 2022-07-21 |
The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b |
Pharmaceutics. 2022 Jul 21;14(7):Article number 1511. |
|
| 2022-06-21 |
Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids |
Pharmaceutics. 2022 Jun 21;14(7):Article number 1316. |
|
| 2022-05-02 |
Furin and TMPRSS2 resistant spike induces robust humoral and cellular immunity against SARS-CoV-2 lethal infection |
Frontiers in Immunology. 2022 May 2;13:Article number 872047. |
|
| 2022-03-02 |
Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy |
Journal of Medicinal Chemistry. 2022 Mar 2;65(6):4767-4782. |
|
| 2022-02-15 |
Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates |
Frontiers in Chemistry. 2022 Feb 15;9:Article number 822587. |
|
| 2021-12 |
Implanted islet mass influences the effects of dipeptidyl peptidase-IV inhibitor LAF237 on transplantation outcomes in diabetic mice |
Biomedical Journal. 2021 Dec;44(6 Suppl 2):S210-S217. |
|
| 2021-11-15 |
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization |
European Journal of Medicinal Chemistry. 2021 Nov 15;224:Article number 113673. |
|
| 2021-10-14 |
Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model |
Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497. |
|
| 2021-10-01 |
Engineering nano- and microparticles as oral delivery vehicles to promote intestinal lymphatic drug transport |
Advanced Materials. 2021 Oct 01;201:Article number 2104139. |
|
| 2021-08-13 |
Remdesivir and cyclosporine synergistically inhibit the human coronaviruses OC43 and SARS-CoV-2 |
Frontiers in Pharmacology. 2021 Aug 13;12:Article number 706901. |
|
| 2021-08-01 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity |
Life Sciences. 2021 Aug 1;278:Article number 119574. |
|
| 2021-08 |
A noninvasive gut-to-brain oral drug delivery system for treating brain tumors |
Advanced Materials. 2021 Aug;33(34):Article number e2100701. |
|
| 2021-05-19 |
Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins |
Journal of Medicinal Chemistry. 2021 May 19;64(11):7312-7330. |
|
| 2021-01 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy |
Translational Oncology. 2021 Jan;14(1):Article number 100897. |
|
| 2021-01 |
Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease |
European Journal of Medicinal Chemistry. 2021 Jan;209:Article number 112938. |
|
| 2020-12-14 |
Inhibition of SARS-CoV-2 by highly potent broad-spectrum anti-coronaviral tylophorine-based derivatives |
Frontiers in Pharmacology. 2020 Dec 14;11:Article number 606097. |
|
| 2020-11 |
Molecular profiling of afatinib-resistant non-small cell lung cancer cells in vivo derived from mice |
Pharmacological Research. 2020 Nov;161:Article number 105183. |
|
| 2020-10-08 |
Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery |
Scientific Reports. 2020 Oct 8;10:Article number 16771. |
|
| 2020-10 |
A bubble bursting-mediated oral drug delivery system that enables concurrent delivery of lipophilic and hydrophilic chemotherapeutics for treating pancreatic tumors in rats |
Biomaterials. 2020 Oct;255:Article number 120157. |
|
| 2020-08-20 |
Discovery of M protease inhibitors encoded by SARS-CoV-2 |
Antimicrobial Agents and Chemotherapy. 2020 Aug 20;64(9):e00872-20. |
|
| 2020-08 |
Artificial intelligence approach fighting COVID-19 with repurposing drugs |
Biomedical Journal. 2020 Aug;43(4):355-362. |
|
| 2020-08 |
Repurposing old drugs as antiviral agents for coronaviruses |
Biomedical Journal. 2020 Aug;43(4):368-374. |
|
| 2020-08 |
BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification |
Cancer Research. 2020 Aug;80(16):1937. |
|
| 2020-02-18 |
Impacts of intralipid on nanodrug abraxane therapy and on the innate immune system |
Scientific Reports. 2020 Feb 18;10:Article number 2838. |
|
| 2019-12 |
A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses |
Antiviral Research. 2019 Dec;172:Article number 104636. |
|
| 2019-12 |
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia |
Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150. |
|
| 2019-11-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123. |
|
| 2019-10 |
Inhibition of Rspo-Wnt pathway facilitates checkpoint blockade therapy by anti-RSPO3 antibody (DBPR117) |
Annals of Oncology. 2019 Oct;30(Suppl. 5):191. |
|
| 2019-09 |
Effects of boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1 |
Phytomedicine. 2019 Sep;62:Article number 152946. |
|
| 2019-08-27 |
A dengue virus type 2 (DENV-2) NS4B-interacting host factor, SERP1, reduces DENV-2 production by suppressing viral RNA replication |
Viruses. 2019 Aug 27;11(9):Article number 787. |
|
| 2019-07-11 |
Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates |
Journal of Medicinal Chemistry. 2019 Jul 11;62(13):6047-6062. |
|
| 2019-07 |
Citronellol induces necroptosis of human lung cancer cells via TNF-alpha pathway and reactive oxygen species accumulation |
In Vivo. 2019 Jul-Aug;33(4):1193-1201. |
|
| 2019-07 |
Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216 |
Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 4626. |
|
| 2019-07 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy |
Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 227. |
|
| 2019-07 |
An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer |
Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 3851. |
|
| 2019-06-15 |
Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems |
Advanced Drug Delivery Reviews. 2019 Jan 15;139(SI):71-82. |
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