| 2019-03 |
Mutagenesis of the dengue virus NS4A protein reveals a novel cytosolic N-terminal domain responsible for virus-induced cytopathic effects and intramolecular interactions within the N-terminus of NS4A |
Journal of General Virology. 2019 Mar;100(3):457-470. |
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| 2019-01 |
CSC-3436 inhibits TWIST-induced epithelial-mesenchymal transition via the suppression of Twist/Bmi1/Akt pathway in head and neck squamous cell carcinoma |
Journal of Cellular Physiology. 2019 Jan;234(6):9118-9129. |
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| 2019-01 |
CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-Beta Wnt and STAT3 signaling pathways |
Journal of Food and Drug Analysis. 2019 Jan;27(1):184-194. |
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| 2018-08-24 |
BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor |
Cancer Science. 2018 Nov;109(11):3591-3601. |
|
| 2018-07 |
An intestinal "Transformers"-like nanocarrier system for enhancing the oral bioavailability of poorly water-soluble drugs |
ACS Nano. 2018 Jul;12(7):6389-6397. |
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| 2018-04 |
Effects of female sex hormones on folic acid-induced anti-angiogenesis |
Acta Physiologica. 2018 Apr;222:Article number e13001. |
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| 2018-04 |
PSPC1 mediates TGF-beta1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis |
Nature Cell Biology. 2018 Apr;20(4):479-491. |
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| 2018-02-08 |
Development of stem-cell-mobilizing agents targeting CXCR4 receptor for peripheral blood stem cell transplantation and beyond |
Journal of Medicinal Chemistry. 2018 Feb 8;61(3):818-833. |
|
| 2018-01-01 |
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2 |
European Journal of Medicinal Chemistry. 2018 Jan 1;143:611-620. |
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| 2017-12 |
Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells |
Free Radical Biology and Medicine. 2017 Dec;113:505-518. |
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| 2017-07-07 |
CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-kappaB pathways |
Scientific Reports. 2017 Jul 07;7(1):Article number 4862. |
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| 2017-07 |
Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors |
Journal of Medicinal Chemistry. 2017 Jul;60(13):5599-5612. |
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| 2017-07 |
Targeting tumor associated phosphatidylserine with new zinc dipicolylamine-based drug conjugates |
Bioconjugate Chemistry. 2017 Jul;28(7):1878-1892. |
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| 2017-05 |
1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine |
Anesthesiology. 2017 May;126(5):952-966. |
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| 2017-04 |
A novel CXCR4 antagonist CX549 induces neuroprotection in stroke brain |
Cell Transplantation. 2017 Apr;26(4):571-583. |
|
| 2016-12 |
Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation |
Oncotarget. 2016 Dec;7(52):86239-86256. |
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| 2016-10 |
BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia |
Molecular Cancer Therapeutics. 2016 Oct;15(10):2323-2333. |
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| 2016-05 |
N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors |
Bioorganic and Medicinal Chemistry. 2016 May;24(10):2242-2250. |
|
| 2015-09 |
Self-assembling bubble carriers for oral protein delivery |
Biomaterials. 2015 Sep;64:115-124. |
|
| 2015-08 |
Novel Nrf2/ARE activator, trans-coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38alpha/MAPKAPK-2 and PK-N3 signaling pathway |
Chemical Research in Toxicology. 2015 Aug ;28(9):1681-1692. |
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| 2015-07 |
Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations |
European Journal of Medicinal Chemistry. 2015 Jul;100:151-161. |
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| 2015-04 |
IL-1beta promotes malignant transformation and tumor aggressiveness in oral cancer |
Journal of Cellular Physiology. 2015 APR;230(4):875-884. |
|
| 2015-03 |
Stem cell mobilizers targeting chemokine receptor CXCR4: Renoprotective application in acute kidney injury |
Journal of Medicinal Chemistry. 2015 Mar;58(5):2315-2325. |
|
| 2014-08-04 |
Effects of dipeptidyl peptidase-4 inhibition with MK-0431 on syngeneic mouse islet transplantation |
International Journal of Endocrinology. 2014 Aug 4;2014:Article ID 795283. |
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| 2014-04 |
Treatment of chemotherapy-induced neutropenia in a rat model by using multiple daily doses of oral administration of G-CSF-containing nanoparticles |
Biomaterials. 2014 Apr;35(11):3641-3649. |
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| 2014-01-08 |
Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer |
PLoS ONE. 2014 Jan 8;9(1):Article number e83160. |
|
| 2013-11 |
BPR0C305, an orally active microtubule-disrupting anticancer agent |
Anticancer Drugs. 2013 Nov;24(10):1047-1057. |
|
| 2013-10 |
Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats |
Journal of Controlled Release. 2013 Oct;172(2):513-522. |
|
| 2013-10 |
Combination therapy via oral co-administration of insulin- and exendin-4-loaded nanoparticles to treat type 2 diabetic rats undergoing OGTT |
Biomaterials. 2013 Oct;34(32):7994-8001. |
|
| 2013-07 |
Andrographis paniculata extract and andrographolide modulate the hepatic drug metabolism system and plasma tolbutamide concentrations in rats |
Evidence-Based Complementary and Alternative Medicine. 2013 Jul;2013:Article number 982689. |
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| 2013-06-28 |
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor |
Journal of Medicinal Chemistry. 2013 Jun 28;56(13):5247-5260. |
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| 2013-06 |
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry. 2013 Jun;21(11):2856-2867. |
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| 2013-06 |
Candida albicans ENO1 null mutants exhibit altered drug susceptibility, hyphal formation, and virulence |
Journal of Microbiology. 2013 Jun;51(3):345-351. |
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| 2013-05 |
H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline in senescent human fetal mesenchymal stem cells |
Antioxidants and Redox Signaling. 2013 May;18(15):1895-1905. |
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| 2013-05 |
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules |
Proceedings of the National Academy of Sciences of the United States of America. 2013 May;110(19):E1779-E1787. |
|
| 2013-01-23 |
In vivo imaging of brain infarct with the novel fluorescent probe psvue 794 in a rat middle cerebral artery occlusion-reperfusion model |
Molecular Imaging. 2013 Jan 23;12(1):8-16. |
|
| 2013-01 |
Effects of pH on molecular mechanisms of chitosan–integrin interactions and resulting tight-junction disruptions |
Biomaterials. 2013 Jan;34(3):784-793. |
|
| 2012-09 |
Elucidating the signaling mechanism of an epithelial tight-junction opening induced by chitosan |
Biomaterials. 2012 Sep;33(26):6254-6263. |
|
| 2012-09 |
Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors |
European Journal of Medicinal Chemistry. 2012 Sep;55:32-38. |
|
| 2012-09 |
Putative tumor metastasis-associated genes in human gastric cancer |
International Journal of Oncology. 2012 Sep;41(3):1068-1084. |
|
| 2012-09 |
HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy |
Clinical Cancer Research. 2012 Sep;18(17):4691-4701. |
|
| 2012-06-07 |
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry Letters. 2012 Jun 7;22(14):4654-4659. |
|
| 2012-04 |
Securin enhances the anti-cancer effects of 6-Methoxy-3-(3′,4′,5′-Trimethoxy-Benzoyl)-1H-Indole (BPR0L075) in human colorectal cancer cells |
PLoS ONE. 2012 Apr;7(4):Article number e36006. |
|
| 2012-03 |
R432 is a key residue for the multiple functions of Ndt80p in Candida albicans |
Cellular and Molecular Life Sciences. 2012 Mar;69(6):1011-1023. |
|
| 2012-02 |
Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents |
Investigational New Drugs. 2012 Feb;30(1):164-175. |
|
| 2012-02 |
Discovery of novel stem cell mobilizers that target the CXCR4 receptor |
ChemMedChem. 2012 Feb;7(2):209-212. |
|
| 2012-01 |
BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML |
British Journal of Cancer. 2012 Jan;106(3):475-481. |
|
| 2011-11 |
Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins |
Biomaterials. 2011 Nov;32(33):8712-8721. |
|
| 2011-10 |
Antiproliferative effects of N-heterocyclic indolyl glyoxylamide derivatives on human lung cancer cells |
Anticancer Research. 2011 Oct;31(10):3407-3415. |
|
| 2011-07 |
Immune response and pathophysiological features of Klebsiella pneumoniae liver abscesses in an animal model |
Laboratory Investigation. 2011 Jul;91(7):1029-1039. |
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