2024-11 |
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration |
Journal of Medicinal Chemistry. 2024 Nov 14;67(21):19777-19790. |
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2024-07-17 |
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia |
Cell Chemical Biology. 2024 Jul 17;Article in Press. |
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2024-06-01 |
Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus |
Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779. |
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2024-02-16 |
Postfermented tea extract potently alleviates glucose metabolism disorders in vitro and in vivo |
ACS Food Science and Technology. 2024 Feb 16;4(2):479-490. |
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2023-07-20 |
Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin |
Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688. |
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2023-02-07 |
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588. |
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2023-01-19 |
The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b [Erratum:Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.] |
Pharmaceutics. 2023 Jan 19;15(2):Article number 342. |
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2022-12-05 |
Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation |
European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728. |
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2022-12-02 |
Omicron-specific mRNA vaccine induced cross-protective immunity against ancestral SARS-CoV-2 infection with low neutralizing antibodies |
Journal of Medical Virology. 2022 Dec 2;95:Article number e28370. |
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2022-11-15 |
BPR0C261, an analogous of microtubule disrupting agent D-24851 enhances the radiosensitivity of human non-small cell lung cancer cells via p53-dependent and p53-independent pathways |
International Journal of Molecular Sciences. 2022 Nov 15;23(22):Article number 14083. |
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2022-11-01 |
Peritoneal effluent MicroRNA profile for detection of encapsulating peritoneal sclerosis |
Clinica Chimica Acta. 2022 Nov 1;536:45-55. |
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2022-11 |
Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone |
Bioorganic Chemistry. 2022 Nov;128:Article number 105905. |
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2022-10-13 |
Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate |
Journal of Medicinal Chemistry. 2022 Oct 13;65(19):12802-12824. |
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2022-10-03 |
Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention |
International Journal of Molecular Sciences. 2022 Oct 3;23(19):Article number 11730. |
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2022-07-21 |
The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b |
Pharmaceutics. 2022 Jul 21;14(7):Article number 1511. |
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2022-06-21 |
Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids |
Pharmaceutics. 2022 Jun 21;14(7):Article number 1316. |
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2022-05-02 |
Furin and TMPRSS2 resistant spike induces robust humoral and cellular immunity against SARS-CoV-2 lethal infection |
Frontiers in Immunology. 2022 May 2;13:Article number 872047. |
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2022-03-02 |
Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy |
Journal of Medicinal Chemistry. 2022 Mar 2;65(6):4767-4782. |
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2022-02-15 |
Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates |
Frontiers in Chemistry. 2022 Feb 15;9:Article number 822587. |
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2021-12 |
Implanted islet mass influences the effects of dipeptidyl peptidase-IV inhibitor LAF237 on transplantation outcomes in diabetic mice |
Biomedical Journal. 2021 Dec;44(6 Suppl 2):S210-S217. |
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2021-11-15 |
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization |
European Journal of Medicinal Chemistry. 2021 Nov 15;224:Article number 113673. |
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2021-10-14 |
Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model |
Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497. |
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2021-10-01 |
Engineering nano- and microparticles as oral delivery vehicles to promote intestinal lymphatic drug transport |
Advanced Materials. 2021 Oct 01;201:Article number 2104139. |
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2021-08-13 |
Remdesivir and cyclosporine synergistically inhibit the human coronaviruses OC43 and SARS-CoV-2 |
Frontiers in Pharmacology. 2021 Aug 13;12:Article number 706901. |
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2021-08-01 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity |
Life Sciences. 2021 Aug 1;278:Article number 119574. |
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