2013-11-21 |
治療癌症的醫藥組成物 |
I415852/2013-11-21 |
|
2013-11-13 |
Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice |
Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933. |
|
2013-11 |
BPR0C305, an orally active microtubule-disrupting anticancer agent |
Anticancer Drugs. 2013 Nov;24(10):1047-1057. |
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2013-10-01 |
喹啉化合物及包含其之治療病毒感染之醫藥組成物 |
I410245/2013-10-01 |
|
2013-09-27 |
Pyrrolidine derivatives |
RU2494094C2/2013-09-27 |
|
2013-09-11 |
噻吩化合物及其醫藥組成物 |
I408136/2013-09-11 |
|
2013-08-21 |
Fused multicyclic compounds as protein kinase inhibitors |
EP2331530B1/2013-08-21 |
|
2013-08-13 |
Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors |
US8507502B2/2013-08-13 |
|
2013-07-16 |
Dibenzo[f,h]isoquinoline derivatives |
US8486959B2/2013-07-16 |
|
2013-07-01 |
做為蛋白質激酶抑制劑之稠合多環化合物 |
I400242/2013-07-01 |
|
2013-06-28 |
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor |
Journal of Medicinal Chemistry. 2013 Jun 28;56(13):5247-5260. |
|
2013-06-05 |
Anticancer oral formulation |
EP2310363B1/2013-06-05 |
|
2013-06 |
c-Jun-mediated anti-cancer mechanisms of tylophorine |
Carcinogenesis. 2013 Jun;34(6):1304-1314. |
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2013-06 |
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry. 2013 Jun;21(11):2856-2867. |
|
2013-05 |
Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus |
Antiviral Research. 2013 May;98(2):228-241. |
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2013-05 |
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules |
Proceedings of the National Academy of Sciences of the United States of America. 2013 May;110(19):E1779-E1787. |
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2013-05 |
Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors |
Journal of Medicinal Chemistry. 2013 May;56(10):3889-3903. |
|
2013-04-30 |
Pyrrolidine derivatives |
164613/2013-04-30 |
|
2013-04-13 |
Exploration of the role of tylophorine E ring in anti-Coronavirus activity-Tylophorine derived dibenzoquinolines impart multi-biological activities as orally active agents |
FASEB Journal. 2013 Apr 13;27:lb71. |
|
2013-04-09 |
Proline derivatives |
US8415482B2/2013-04-09 |
|
2013-04-07 |
BPR000K, a novel Aurora kinase inhibitor |
Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 300-MEDI. |
|
2013-04-07 |
3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor |
Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 87-MEDI. |
|
2013-04-07 |
Development drug candidate targeting EGFR kinase: DBPR112 |
Abstracts of Papers - American Chemical Society. 2013 Apr 7;245:Article number 299-MEDI. |
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2013-04 |
Tylophorine induces c-Jun protein accumulation through two discrete prolonged pathways NF-kappaB/PKCdelta/JNK and PI3K/PDK1/PP2A/eEF2 to promote G1 arrest in carcinoma cells |
FASEB Journal. 2013 Apr;27:lb74. |
|
2013-04 |
Identification of a quinone compound inhibits human glutaminase activity and induces autophagy in carcinoma cells |
FASEB Journal. 2013 Apr;27:lb70. |
|
2013-04 |
Design and synthesis of Aurora kinase inhibitors as anticancer agents |
Abstracts of Papers - American Chemical Society. 2013 Apr;245:Article number 301-MEDI. |
|
2013-03-27 |
Thiophene compounds |
EP2068870/2013-03-27 |
|
2013-02-11 |
吡咯啉啶化合物 |
I385163/2013-02-11 |
|
2013-02-11 |
抗癌口服藥學組成物 |
I384984/2013-02-11 |
|
2013-02-11 |
作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物 |
I385174/2013-02-11 |
|
2013-02 |
Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems |
Antimicrobial Agents and Chemotherapy. 2013 Feb; 57(2):723-733. |
|
2013-01-15 |
Imidazol-4-one and imidazole-4-thione compounds |
US8354442B2/2013-01-15 |
|
2013-01 |
3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor |
ChemMedChem. 2013 Jan;8(1):136-148. |
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2012-12-13 |
Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: Exploration of the role of tylophorine e ring on biological activity |
Journal of Medicinal Chemistry. 2012 Dec 13;55(23):10363-10377. |
|
2012-12 |
An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold |
Journal of the Chinese Chemical Society. 2012 Dec;59(12):1548-1554. |
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2012-11 |
BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia |
European Journal of Cancer. 2012 Nov;48(Suppl. 6):53-54. |
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2012-09 |
Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization |
ChemMedChem. 2012 Sep;7(9):1546-1550. |
|
2012-09 |
Putative tumor metastasis-associated genes in human gastric cancer |
International Journal of Oncology. 2012 Sep;41(3):1068-1084. |
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2012-07-04 |
噻吩化合物 |
ZL200780036897.1/2012-07-04 |
|
2012-07 |
Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors |
International Journal of Obesity. 2012 Jul;36(7):999-1006. |
|
2012-06-15 |
Pyrrolidine derivatives |
587911/2012-06-15 |
|
2012-06-12 |
Treatment of neurodegenerative disorders with thiourea compounds |
US8198284B2/2012-06-12 |
|
2012-06-07 |
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry Letters. 2012 Jun 7;22(14):4654-4659. |
|
2012-06 |
EGFR and myosin II inhibitors cooperate to suppress EGFR-T790M-mutant NSCLC cells |
Molecular Oncology. 2012 Jun;6(3):299-310. |
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2012-05-11 |
作為極光激酶抑制劑之稠合雙環嘧啶化合物 |
I363627/2012-05-11 |
|
2012-04-21 |
吡咯啉啶化合物 |
I362388/2012-04-21 |
|
2012-04-11 |
咪唑啉酮及咪唑啉硫酮衍生物 |
I361808/2012-04-11 |
|
2012-03-25 |
Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors |
Abstracts of Papers - American Chemical Society. 2012 Mar 25;243:Article number 48-MEDI. |
|
2012-03-20 |
Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
US8138194B2/2012-03-20 |
|
2012-03-01 |
C型肝炎病毒抑制劑 |
I359137/2012-03-01 |
|