| 2012-06-07 |
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry Letters. 2012 Jun 7;22(14):4654-4659. |
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| 2012-06 |
EGFR and myosin II inhibitors cooperate to suppress EGFR-T790M-mutant NSCLC cells |
Molecular Oncology. 2012 Jun;6(3):299-310. |
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| 2012-05-11 |
作為極光激酶抑制劑之稠合雙環嘧啶化合物 |
I363627/2012-05-11 |
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| 2012-04-11 |
咪唑啉酮及咪唑啉硫酮衍生物 |
I361808/2012-04-11 |
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| 2012-03-25 |
Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors |
Abstracts of Papers - American Chemical Society. 2012 Mar 25;243:Article number 48-MEDI. |
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| 2012-03-20 |
Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
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| 2012-03-01 |
C型肝炎病毒抑制劑 |
I359137/2012-03-01 |
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| 2012-02 |
Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents |
Investigational New Drugs. 2012 Feb;30(1):164-175. |
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| 2012-02 |
Identification of BPR3P0128 as an Inhibitor of cap-snatching activities of influenza virus |
Antimicrobial Agents and Chemotherapy. 2012 Feb;56(2):647-657. |
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| 2012-01 |
Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor |
Antimicrobial Agents and Chemotherapy. 2012 Jan;56(1):44-53. |
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| 2012-01 |
BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML |
British Journal of Cancer. 2012 Jan;106(3):475-481. |
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| 2012-01 |
A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors |
Anticancer Research. 2012 Jan;32(1):147-151. |
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| 2011-12 |
Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism |
Biotechnology and Bioengineering. 2011 Dec;108(12):2932-2940. |
|
| 2011-09-23 |
BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo |
European Journal of Cancer. 2011 Sep 23;47:S127. |
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| 2011-09 |
Overcoming the acquired resistance to Afatinib (BIBW2992) in HCC827, a non-small cell lung cancer cell line |
European Journal of Cancer. 2011 Sep;47:S129. |
|
| 2011-09 |
Suppression of stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells |
European Journal of Cancer. 2011 Sep;47(Suppl. 1):S104. |
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| 2011-08 |
BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells |
PLoS ONE. 2011 Aug;6(8):Article number e23485. |
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| 2011-07-26 |
Hepatitis C virus inhibitors |
US7985763B2/2011-07-26 |
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| 2011-07-11 |
抑制C型肝炎病毒感染之倍半帖內酯類化合物及其醫藥組成物 |
I344959/2011-07-11 |
|
| 2011-07 |
Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry. 2011 Jul;19(14):4173-4182 . |
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| 2011-06-21 |
抑制冠狀病毒之醫藥組合物 |
I343809/2011-06-21 |
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| 2011-06-21 |
抑制冠狀病毒之醫藥組合物 |
I343808/2011-06-21 |
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| 2011-06-21 |
抑制冠狀病毒之醫藥組合物 |
I343810/2011-06-21 |
|
| 2011-06-01 |
Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells |
Biochemical Pharmacology. 2011 Jun 01;81(11):1263-1270. |
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| 2011-06 |
Synergistic inhibition of enterovirus 71 replication by interferon and rupintrivir |
Journal of Infectious Diseases. 2011 Jun;203(12):1784-1790. |
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| 2011-05-10 |
Imidazolidinone and imidazolidinethione derivatives |
US7939523B2/2011-05-10 |
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| 2011-04-25 |
Diosgenin, a plant-derived sapogenin, exhibits antiviral activity in vitro against hepatitis C virus |
Journal of Natural Products. 2011 Apr 25;74(4):580-584. |
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| 2011-04 |
Isatin-beta-thiosemicarbazones as potent herpes simplex virus inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2011 Apr;21(7):1948-1952. |
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| 2011-03-27 |
Design and synthesis of potent Aurora kinase inhibitors |
Abstracts of Papers - American Chemical Society. 2011 Mar 27;241:258-MEDI. |
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| 2011-03-01 |
Thiourea derivatives |
US7897764B2/2011-03-01 |
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| 2011-03 |
Potent EGFR tyrosine kinase inhibitors as anticancer agents |
Abstracts of Papers - American Chemical Society. 2011 Mar;241:257-MEDI. |
|
| 2011-03 |
SAR studies of quinoline derivatives as novel anti-influenza agents |
Abstracts of Papers - American Chemical Society. 2011 Mar;241:81-MEDI. |
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| 2011-02 |
Synthesis of 3,3-dimethylglutamic acid derivatives as DPP-IV inhibitors and evaluation of their chemical stability |
Journal of the Chinese Chemical Society. 2011 Feb;58(1):108-117. |
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| 2010-12-01 |
吲哚化合物 |
ZL200480034988.8/2010-12-01 |
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| 2010-10-28 |
Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency |
Journal of Medicinal Chemistry. 2010 Oct 28;53(20):7316-7326. |
|
| 2010-10 |
Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists |
ChemMedChem. 2010 Oct;5(10):1707-1716. |
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| 2010-08-21 |
硫尿化合物及抑制C型肝炎病毒感染之方法 |
I329102/2010-08-21 |
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| 2010-08 |
Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models |
Abstracts of Papers - American Chemical Society. 2010 Aug;240:MEDI 332. |
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| 2010-06-15 |
Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification |
Journal of Medicinal Chemistry. 2010 Jun 15;53(13):4980-4988. |
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| 2010-04 |
Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid |
Journal of Antimicrobial Chemotherapy. 2010 Apr;65(4):676-683. |
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| 2010-02-23 |
Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity |
Journal of Biomedical Science. 2010 Feb 23;17:Article number 13. |
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| 2010-02-01 |
Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor |
ChemMedChem. 2010 Feb 1;5(2):255-267. |
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| 2010-01 |
BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses |
Journal of Antimicrobial Chemotherapy. 2010 Jan;65(1):63-71. |
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| 2009-11-01 |
Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Nov 1;19(21):6063-6068. |
|
| 2009-11 |
Development of NS3/4A protease-based reporter assay suitable for efficiently assessing hepatitis C virus infection |
Antimicrobial Agents and Chemotherapy. 2009 Nov;53(11):4825-4834. |
|
| 2009-09 |
Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development |
EJC Supplements. 2009 Sep;7(2):96. |
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| 2009-08-01 |
Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2009 Aug 1;19(15):4134-4138. |
|
| 2009-07 |
Novel antiviral agent DTriP-22 targets RNA-dependent RNA polymerase of enterovirus 71 |
Antimicrobial Agents and Chemotherapy. 2009 Jul;53(7):2740-2747. |
|
| 2009-06-09 |
Treatment of coronavirus infection |
US7544712B1/2009-06-09 |
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| 2009-04-23 |
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists |
Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622. |
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