| Abstract: | 本發明提供一種硫尿化合物，具有下列化學式(I)：其中每一R1 、R2 與R3 獨立地包括氫、C1 －C10 烷基、C2 －C10 烯基、C2 －C10 炔基、C3 －C20 環烷基、C3 －C20 環烯基、C1 －C20 異環烷基、C1 －C20 異環烯基、芳基或異芳基或R1 與R2 與一氮原子鍵結形成C3 －C20 異環烷基或R2 與R3 與二氮原子鍵結形成C3 －C20 異環烷基；每一A1 與A2 獨立地包括芳基或異芳基；每一X、Y與Z獨立地包括O、S、S(O)、S(O)2 、N(Ra )、C(Ra Rb )、C1 －C10 烷基、C2 －C10 烯基、C2 －C10 炔基、C3 －C20 環烷基、C1 －C20 異環烷基、芳基或異芳基，每一Ra 與Rb 獨立地包括氫、C1 －C10 烷基、C3 －C20 環烷基、C1 －C20 異環烷基、芳基或異芳基；每一m與n獨立地為1、2、3、4或5；以及每一x、y與z獨立地為0或1。該硫尿化合物可用於抑制C型肝炎病毒感染。A thiourea compound of formula (I) is provided,wherein each of R1 , R2 and R3 , independently, is H, C1 -C10 alkyl, C2 -C10 alkenyl, C2 -C10 alkynyl, C3 -C20 cycloalkyl, C3 -C20 cycloalkenyl, C1 -C20 heterocycloalkyl, C1 -C20 heterocycloalkenyl, aryl or heteroaryl, or R1 and R2 , together with the nitrogen atom to which they are bonded, are C3 -C20 heterocycloalkyl, or R2 and R3 , together with the two nitrogen atoms to which they are bonded and the carbon atom bonded to both of the two nitrogen atoms, are C3 -C20 heterocycloalkyl, each of A1 and A2 , independently, is aryl or heteroaryl, each of X, Y, and Z, independently, is O, S, S(O), S(O)2 , N(Ra ), C(Ra Rb ), C1 -C10 alkyl, C2 -C10 alkenyl, C2 -C10 alkynyl, C3 -C20 cycloalkyl, C1 -C20 heterocycloalkyl, aryl or heteroaryl, in which each of Ra and Rb , independently, is H, C1 -C10 alkyl, C3 -C20 cycloalkyl, C1 -C20 heterocycloalkyl, aryl or heteroaryl, each of m and n, independently, is 1, 2, 3, 4 or 5, and each of x, y and z, independently, is 0 or 1. The compound can be used to inhibit hepatitis C virus infection. |
