| 2024-02-15 |
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice |
Biochemical and Biophysical Research Communications. 2024 Feb 15;704:Article number 149668. |
 |
| 2023-07-20 |
Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin |
Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688. |
|
| 2023-01-19 |
The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b [Erratum:Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.] |
Pharmaceutics. 2023 Jan 19;15(2):Article number 342. |
|
| 2022-07-21 |
The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b |
Pharmaceutics. 2022 Jul 21;14(7):Article number 1511. |
|
| 2022-02-17 |
Tyrphostin AG1024 suppresses coronaviral replication by downregulating JAK1 via an IR/IGF-1R independent proteolysis mediated by Ndfip1/2_NEDD4-like E3 ligase itch |
Pharmaceuticals. 2022 Feb 17;15(2):Article number 241. |
|
| 2021-08-13 |
Remdesivir and cyclosporine synergistically inhibit the human coronaviruses OC43 and SARS-CoV-2 |
Frontiers in Pharmacology. 2021 Aug 13;12:Article number 706901. |
|
| 2020-12-14 |
Inhibition of SARS-CoV-2 by highly potent broad-spectrum anti-coronaviral tylophorine-based derivatives |
Frontiers in Pharmacology. 2020 Dec 14;11:Article number 606097. |
|
| 2020-12 |
Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na(+)/K(+)-ATPase independent proteolysis[Erratum:Biochemical Pharmacology. 2020 Oct;180:Article number 114122.] |
Biochemical Pharmacology. 2020 Dec;182:Article number 114287. |
|
| 2020-10 |
Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na(+)/K(+)-ATPase independent proteolysis |
Biochemical Pharmacology. 2020 Oct;180:Article number 114122. |
|
| 2020-08-20 |
Discovery of M protease inhibitors encoded by SARS-CoV-2 |
Antimicrobial Agents and Chemotherapy. 2020 Aug 20;64(9):e00872-20. |
|
| 2020-08 |
Polyketide synthase gene expression in relation to chloromonilicin and melanin production in Monilinia fructicola |
Phytopathology. 2020 Aug;110(8):1465-1475. |
|
| 2020-08 |
Artificial intelligence approach fighting COVID-19 with repurposing drugs |
Biomedical Journal. 2020 Aug;43(4):355-362. |
|
| 2020-08 |
Repurposing old drugs as antiviral agents for coronaviruses |
Biomedical Journal. 2020 Aug;43(4):368-374. |
|
| 2020-02 |
The cardenolides ouabain and reevesioside A promote FGF2 secretion and subsequent FGFR1 phosphorylation via converged ERK1/2 activation |
Biochemical Pharmacology. 2020 Feb;172:Article number 113741. |
|
| 2020-02 |
Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1alpha |
Pharmacological Research. 2020 Feb;152:Article number 104581. |
|
| 2019-08-06 |
Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: An identification of a novel oncotarget[Erratum: Oncotarget. 2015 Feb;6(4):2148-2163.] |
Oncotarget. 2019 Aug 6;10(47):4919. |
|
| 2018-10 |
The cardenolide ouabain suppresses coronaviral replication via augmenting a Na(+)/K(+)-ATPase-dependent PI3K_PDK1 axis signaling |
Toxicology and Applied Pharmacology. 2018 Oct;56:90-97. |
|
| 2017-10 |
Identification of anti-viral activity of the cardenolides, Na+/K+-ATPase inhibitors, against porcine transmissible gastroenteritis virus |
Toxicology and Applied Pharmacology. 2017 Oct;332:129-137. |
|
| 2017-07 |
Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors |
Journal of Medicinal Chemistry. 2017 Jul;60(13):5599-5612. |
|
| 2017-06-22 |
Targeting coronaviral replication and cellular JAK2 mediated dominant NF-kappaB activation for comprehensive and ultimate inhibition of coronaviral activity |
Scientific Reports. 2017 Jun 22;7:Article number 4105. |
|
| 2017-05-22 |
Bioactive composition of Reevesia formosana root and stem with cytotoxic activity potential |
RSC Advances. 2017 May 22;7(43):27040-27047. |
|
| 2016-10 |
Cytotoxic cardenolides and sesquiterpenoids from the fruits of Reevesia formosana |
Phytochemistry. 2016 Oct;130:282-290. |
|
| 2016-04 |
Discovery and development of tylophorine derived dibenzoquinolines-33b compounds into therapeutic agents |
The FASEB Journal. 2016 Apr;30(1, Suppl.):Meeting Abstract lb56. |
 |
| 2016-02-22 |
Guidelines for the use and interpretation of assays for monitoring autophagy [Erratum to: Autophagy. 2016 Jan 2;12(1):1-222.] |
Autophagy. 2016 Feb 22;12(2):443. |
|
| 2016-01-02 |
Guidelines for the use and interpretation of assays for monitoring autophagy |
Autophagy. 2016 Jan 2;12(1):1-222. |
|
| 2015-07 |
Biological evaluation of secondary metabolites from the root of machilus obovatifolia |
Chemistry and Biodiversity. 2015 Jul;12(7):1057-1067. |
|
| 2015-04 |
Tylophorine compounds exert anti-cancer activity by targeting a ribonucleoprotein complex containing caprin-1 and c-Myc mRNA |
FASEB Journal. 2015 Apr;29(1, Suppl.):Abstract number LB132 |
|
| 2015-02 |
Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: An identification of a novel oncotarget |
Oncotarget. 2015 Feb;6(4):2148-2163. |
|
| 2014-11 |
Chemical constituents and cytotoxic activities from the fruits of Reevesia formosana |
Planta Medica. 2014 Nov;80(16):1541. |
|
| 2014-11 |
Chemical constituents and cytotoxic activities from the root and the stem of Reevesia formosana |
Planta Medica. 2014 Nov;80(16):1541. |
|
| 2014-08 |
Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells |
Oncotarget. 2014 Aug;5(15):6087-6101. |
|
| 2014-05-11 |
二苯並〔f,h〕異喹啉衍生物及其醫藥組成物 |
I436983/2014-05-11 |
|
| 2014-03-21 |
菲并吲哚啶類似物 |
I430794/2014-03-21 |
|
| 2014-01 |
A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease |
Antimicrobial Agents and Chemotherapy. 2014 Jan;58(1):110-119. |
|
| 2013-07-16 |
Dibenzo[f,h]isoquinoline derivatives |
US8486959B2/2013-07-16 |
|
| 2013-06 |
c-Jun-mediated anti-cancer mechanisms of tylophorine |
Carcinogenesis. 2013 Jun;34(6):1304-1314. |
|
| 2013-05-14 |
Phenanthroindolizidine analogues |
US8440649B2/2013-05-14 |
|
| 2013-04-13 |
Exploration of the role of tylophorine E ring in anti-Coronavirus activity-Tylophorine derived dibenzoquinolines impart multi-biological activities as orally active agents |
FASEB Journal. 2013 Apr 13;27:lb71. |
|
| 2013-04 |
Tylophorine induces c-Jun protein accumulation through two discrete prolonged pathways NF-kappaB/PKCdelta/JNK and PI3K/PDK1/PP2A/eEF2 to promote G1 arrest in carcinoma cells |
FASEB Journal. 2013 Apr;27:lb74. |
|
| 2013-04 |
Identification of a quinone compound inhibits human glutaminase activity and induces autophagy in carcinoma cells |
FASEB Journal. 2013 Apr;27:lb70. |
|
| 2013-03 |
Cytotoxic cardenolide glycosides from the root of Reevesia formosana |
Phytochemistry. 2013 Mar;87:86-95. |
|
| 2012-12-13 |
Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: Exploration of the role of tylophorine e ring on biological activity |
Journal of Medicinal Chemistry. 2012 Dec 13;55(23):10363-10377. |
|
| 2011-11 |
Isolation and biological activities of phenanthroindolizidine and septicine alkaloids from the formosan tylophora ovata |
Planta Medica. 2011 Nov;77(17):1932-1938. |
|
| 2011-01 |
Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay |
Antimicrobial Agents and Chemotherapy. 2011 Jan;55(1):229-238. |
|
| 2011-01 |
Antitubercular resorcinol analogs and benzenoid C-glucoside from the roots of ardisia cornudentata |
Planta Medica. 2011 Jan;77(1):60-65. |
|
| 2010-11 |
Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus |
Antiviral Research. 2010 Nov;88(2):160-168. |
|
| 2010-11 |
Cytotoxic Sesquiterpenes from Magnolia kachirachirai |
Chemistry and Biodiversity. 2010 Nov;7(11):2737-2747. |
|
| 2010-10-11 |
乙烯磺酸鹽化合物 |
I331523/2010-10-11 |
|
| 2010-09 |
Cytotoxic flavonoids from the leaves of cryptocarya chinensis |
Journal of Natural Products. 2010 Sep;73(9): 1470-1475. |
|
| 2010-04-20 |
A new butanolide and a new secobutanolide from Litsea lii var. nunkao-tahangensis |
Natural Product Research. 2010 Apr 20;24(7):647-656. |
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