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http://ir.nhri.org.tw/handle/3990099045/5844
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| Title: | Isolation and biological activities of phenanthroindolizidine and septicine alkaloids from the formosan tylophora ovata |
| Authors: | Lee, YZ;Huang, CW;Yang, CW;Hsu, HY;Kang, IJ;Chao, YS;Chen, IS;Chang, HY;Lee, SJ |
| Contributors: | Institute of Biotechnology and Pharmaceutical Research |
| Abstract: | An investigation of alkaloids present in the leaves and stems of Tylophora ovata led to the isolation of two new septicine alkaloids and one new phenanthroindolizidine alkaloid, tylophovatines A, B, C (1, 2, and 5), respectively, together with two known septicine and six known phenanthroindolizidine alkaloids. The structures of the new alkaloids 1, 2, and 5 were established by means of spectroscopic analyses. These eleven alkaloids show in vitro anti-inflammatory activities with IC50 values ranging from 84 nM to 20.6 μM through their suppression of nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharide and interferon-γ. Moreover, these substances display growth inhibition in HONE-1, NUGC-3, HepG2, SF-268, MCF-7, and NCI-H460 cancer cell lines, with GI50 values ranging from 4 nM to 24.2 μM. In addition, tylophovatine C (5) and 13a(S)-(+)-tylophorine (7) were found to exhibit potent in vivo anti-inflammation activities in a rat paw edema model. Finally, structure-activity relationships were probed by using the isolated phenanthroindolizidines and septicines. Phenanthroindolizidines are suggested to be divided into cytotoxic agents (e.g., 10 and 11) and anti-inflammation based anticancer agents (e.g., 5-9). |
| Date: | 2011-11 |
| Relation: | Planta Medica. 2011 Nov;77(17):1932-1938. |
| Link to: | http://dx.doi.org/10.1055/s-0030-1271199 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000298851200011 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=81855217515 |
| Appears in Collections: | [李秀珠] 期刊論文
[趙宇生(2002-2013)] 期刊論文
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Files in This Item:
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Description |
Size | Format | |
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| SCP79959792654.pdf | | 243Kb | Adobe PDF | 720 | View/Open |
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