國家衛生研究院 NHRI:Items for Author

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Items for Author "Shiao, HY"

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Showing 45 items.

Collection	Date	Title	Relation
[伍素瑩] 期刊論文	2019-04-10	Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants	-
[喻秋華] 期刊論文	2019-05-28	Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform	-
[張俊彥] 期刊論文	2011-08	BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells	-
[徐祖安] 會議論文/會議摘要	2014-03	DBPR112, a potent and selective EGFR kinase inhibitor in preclinical study	-
[徐祖安] 會議論文/會議摘要	2011-03	Potent EGFR tyrosine kinase inhibitors as anticancer agents	-
[徐祖安] 期刊論文	2015-01	Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity	-
[徐祖安] 期刊論文	2014-05	Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014)	-
[徐祖安] 期刊論文	2013-09-22	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411]	-
[徐祖安] 期刊論文	2013-05	Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors	-
[徐祖安] 期刊論文	2013-04-29	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment	-
[李靜琪] 期刊論文	2023-10-05	Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease	-
[葉燈光] 會議論文/會議摘要	2017-04	Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	-
[葉燈光] 會議論文/會議摘要	2013-11	A development drug candidate targeting EGFR kinase for lung cancer: DBPR112	-
[蔣維棠] 期刊論文	2019-12	Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia	-
[謝興邦] 會議論文/會議摘要	2017-04	Toward the total syntheses of natural products containing trans-decalin skeleton from masked o-benzoquinone	-
[謝興邦] 會議論文/會議摘要	2015-08	Optimization of furanopyrimidine-based kinase inhibitors: Identification of a BTK kinase inhibitor for the treatment of B cell lymphoma	-
[謝興邦] 會議論文/會議摘要	2015-08	Discovery of 2,4-diaminopyrimidines bearing a unique pharmacophore as anaplastic lymphoma kinase inhibitors	-
[謝興邦] 會議論文/會議摘要	2014-10	Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML	-
[謝興邦] 會議論文/會議摘要	2014-10	Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma	-
[謝興邦] 會議論文/會議摘要	2014-03	Efficient virtual screening using ligand efficiency based approach	-
[謝興邦] 會議論文/會議摘要	2013-04-07	3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor	-
[謝興邦] 會議論文/會議摘要	2013-04	Design and synthesis of Aurora kinase inhibitors as anticancer agents	-
[謝興邦] 會議論文/會議摘要	2012-03-25	Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors	-
[謝興邦] 期刊論文	2019-11-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	-
[謝興邦] 期刊論文	2018-11	Biomimetic Syntheses of (±)‐Isopalhinine A, (±)‐Palhinine A, and (±)‐Palhinine D	-
[謝興邦] 期刊論文	2017-07	Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors	-
[謝興邦] 期刊論文	2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	-
[謝興邦] 期刊論文	2014-10	Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer	-
[謝興邦] 期刊論文	2014-08	Ligand efficiency based approach for efficient virtual screening of compound libraries	-
[謝興邦] 期刊論文	2014-07	Anaplastic lymphoma kinase (ALK) inhibitors: A review of design and discovery	-
[謝興邦] 期刊論文	2014-05	Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach	-
[謝興邦] 期刊論文	2013-06-28	Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor	-
[謝興邦] 期刊論文	2013-05	Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	-
[謝興邦] 期刊論文	2013-01	3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor	-
[謝興邦] 期刊論文	2012-12	An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold	-
[謝興邦] 期刊論文	2012-09	Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization	-
[謝興邦] 期刊論文	2011-09	Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway	-
[謝興邦] 期刊論文	2011-04-28	Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-Fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents	-
[謝興邦] 期刊論文	2010-06-15	Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification	-
[謝興邦] 期刊論文	2010-02-25	Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives	-
[謝興邦] 期刊論文	2008-02-07	First total syntheses of (+/-)-annuionone B and (+/-)-tanarifuranonol	-
[趙宇生(2002-2013)] 期刊論文	2010-10-28	Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency	-
[趙宇生(2002-2013)] 期刊論文	2010-10	Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists	-
[陳炯東] 會議論文/會議摘要	2016-12	Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST	-
[陳炯東] 會議論文/會議摘要	2015-08	Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia	-

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Items for Author "Shiao, HY"