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生技與藥物研究所
李靜琪
--期刊論文
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Decrypting orphan GPCR drug discove...
Discovery of tetrasubstituted thiop...
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Design, synthesis, and anticancer e...
Discovery of potential neuroprotect...
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Delayed intervention with a novel S...
Identification of an oxime-containi...
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2024-04
Design, synthesis, and anticancer evaluation of 1-benzo[1,3]dioxol-5-yl-3-N-fused heteroaryl indoles
Molecular Diversity. 2024 Apr;28(2):595-608.
2024-01-23
Decrypting orphan GPCR drug discovery via multitask learning
Journal of Cheminformatics. 2024 Jan 23;16:Article number 10.
2023-10-05
Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease
European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115583.
2023-03-17
A convenient diels-alder approach toward potential polyketide-like antibiotics using alpha-activated alpha,Beta-unsaturated 4,4-dimethyl-1-tetralones as dienophiles
Molecules. 2023 Mar 17;28(6):Article number 2739.
2022-03-02
Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy
Journal of Medicinal Chemistry. 2022 Mar 2;65(6):4767-4782.
2020-02
Design, synthesis and anticancer evaluation of beta-carboline-1-one hydantoins
Future Medicinal Chemistry. 2020 Feb;12(3):183-192.
2020-01-01
Delayed intervention with a novel SGLT2 inhibitor NGI001 suppresses diet-induced metabolic dysfunction and nonalcoholic fatty liver disease in mice
British Journal of Pharmacology. 2020 Jan 1;177(2):239-253.
2019-03
Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors
Bioorganic Chemistry. 2019 Mar;83:520-525.
2018-01-01
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2
European Journal of Medicinal Chemistry. 2018 Jan 1;143:611-620.
2016-12-08
Bromomethylthioindole inspired carbazole hybrids as promising class of anti-MRSA agents
ACS Medicinal Chemistry Letters. 2016 Dec 8;7(12):1191-1196.
2016-09
Mycotoxin patulin suppresses innate immune responses by mitochondrial dysfunction and p62/sequestosome-1-dependent mitophagy
Journal of Biological Chemistry. 2016 Sep;291(37):19299-19311.
2016-07
Total synthesis of the naturally occurring glycosylflavone aciculatin
Journal of Natural Products. 2016 Jul;79(7):1719-1723.
2016-05
N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors
Bioorganic and Medicinal Chemistry. 2016 May;24(10):2242-2250.
2015-07
Development and application of a fluorescent glucose uptake assay for the high-throughput screening of non-glycoside SGLT2 inhibitors
European Journal of Pharmaceutical Sciences. 2015 Jul;74:40-44.
2014-09
N-Iodosuccinimide and acid-washed molecular sieves (NIS/AW-300 MS) as promoters in thioglycoside activation
Tetrahedron. 2014 Sep;70(38):6757-6762.
2014-08
Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells
Oncotarget. 2014 Aug;5(15):6087-6101.
2012-09
Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors
European Journal of Medicinal Chemistry. 2012 Sep;55:32-38.
2011-08
Colloid-based multiplexed screening for plant biomass-degrading glycoside hydrolase activities in microbial communities
Energy and Environmental Science. 2011 Aug;4(8):2884-2893.
2011-07-25
The first total synthesis of cytopiloyne, an anti-diabetic, polyacetylenic glucoside
Chemistry-A European Journal. 2011 Jul 25;17(31):8696-8703.
2011-06
Development of sodium-dependent glucose co-transporter 2 inhibitors as potential anti-diabetic therapeutics
Current Topics In Medicinal Chemistry. 2011 Jun;11(12):1476-1512.
2011-01-13
Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
Journal of Medicinal Chemistry. 2011 Jan 13;54(1):166-178.
2010-12
Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening
Journal of Medicinal Chemistry. 2010 Dec;53(24):8770-8774.
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