國家衛生研究院 NHRI:
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    近3年内发表的文件:19(12.10%)
    含全文笔数:157(100.00%)

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    最后更新时间: 2024-12-01 14:05


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    显示项目101-125 / 157. (共7页)
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    日期题名關聯
    2011-07 Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) Bioorganic and Medicinal Chemistry. 2011 Jul;19(14):4173-4182 .
    2011-05 Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4 Journal of Agricultural and Food Chemistry. 2011 May;59(9):4644-4648.
    2011-01-13 Discovery of novel N -Beta- d -Xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes Journal of Medicinal Chemistry. 2011 Jan 13;54(1):166-178.
    2011-01 BPR0C261 is a novel orally active antitumor agent with antimitotic and anti-angiogenic activities Cancer Science. 2011 Jan;102(1):182-191.
    2010-12 Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening Journal of Medicinal Chemistry. 2010 Dec;53(24):8770-8774.
    2010-11 Self-assembled pH-sensitive nanoparticles: A platform for oral delivery of protein drugs Advanced Functional Materials. 2010 Nov;20(21):3695-3700.
    2010-11 Do neutrophils play a role in establishing liver abscesses and distant metastases caused by Klebsiella pneumoniae? PLoS ONE. 2010 Nov;5(11):Article number e15005.
    2010-10-28 Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency Journal of Medicinal Chemistry. 2010 Oct 28;53(20):7316-7326.
    2010-09 Intravenous paclitaxel against metastasis of human gastric tumors of diffuse type Cancer Chemotherapy and Pharmacology. 2010 Sep;66(4):773-783.
    2010-07 Antiangiogenic Activities and Cisplatin-combined Antitumor Activities of BPR0L075 Anticancer Research. 2010 Jul;30(7):2813-2822.
    2010-06-15 (2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV Bioorganic and Medicinal Chemistry Letters. 2010 Jun 15;20(12):3596-3600.
    2010-03 Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice Obesity. 2010 Mar;18(3):463-469.
    2010-03 Synthesis and biological activities of 2-Amino-1-arylidenamino imidazoles as orally active anticancer agents Journal of Medicinal Chemistry. 2010 Mar;53(6):2409-2417.
    2010-02 Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91 Pharmacological Research. 2010 Feb;61(2):108-115.
    2010-02 Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice International Journal of Obesity. 2010 Feb;34(2):227-239.
    2009-10 (1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055.
    2009-08-13 Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach Journal of Medicinal Chemistry. 2009 Aug 13;52(15):4941-4945.
    2009-07-23 Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4221-4233.
    2009-07 Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes Food and Chemical Toxicology. 2009 Jul;47(7):1703-1709.
    2009-04-01 Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912.
    2009-04 In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery Biomaterials. 2009 Apr;30(12):2329-2339.
    2009-03-15 Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors Bioorganic and Medicinal Chemistry. 2009 Mar 15;17(6):2388-2399.
    2009-03 Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells Mycological Research. 2009 Mar;113(3):388-390.
    2008-11-28 Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10) Cancer Letters. 2008 Nov 28;271(2):294-305.
    2008-09 Human breast tumor cells express multimodal imaging reporter genes Molecular Imaging and Biology. 2008 Sep;10(5):253-263.

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