國家衛生研究院 NHRI:Item 3990099045/9884
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 855549      線上人數 : 1200
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9884


    題名: Mycotoxin patulin suppresses innate immune responses by mitochondrial dysfunction and p62/sequestosome-1-dependent mitophagy
    作者: Tsai, WT;Lo, YC;Wu, MS;Li, CY;Kuo, YP;Lai, YH;Tsai, Y;Chen, KC;Chuang, TH;Yao, CH;Lee, JC;Hsu, LC;Hsu, JT;Yu, GY
    貢獻者: Division of Infectious Diseases;Immunology Research Center;Institute of Biotechnology and Pharmaceutical Research
    摘要: Innate immune responses are important for pathogen elimination and adaptive immune response activation. However, excess inflammation may contribute to immunopathology and disease progression, e.g. inflammation-associated hepatocellular carcinoma. Immune modulation resulting from pattern recognition receptor (PRR)-induced responses is a potential strategy for controlling immunopathology and related diseases. This study demonstrates that the mycotoxin patulin suppresses Toll-like receptor (TLR)- and RIG-I/MAVS-dependent cytokine production through GSH depletion, mitochondrial dysfunction, the activation of p62-associated mitophagy and p62-TRAF6 interaction. Blockade of autophagy restored the immunosuppressive activity of patulin and pharmmacological activation of p62-dependent mitophagy directly reduced RLR-dependent inflammatory cytokine production. These results demonstrated that p62-dependent mitophagy has an immunosuppressive role to innate immune response and might serve as a potential immunomodulatory target for inflammation-associated diseases.
    日期: 2016-09
    關聯: Journal of Biological Chemistry. 2016 Sep;291(37):19299-19311.
    Link to: http://dx.doi.org/10.1074/jbc.M115.686683
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1083-351X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000383242800011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84986877476
    顯示於類別:[余冠儀] 期刊論文
    [莊宗顯] 期刊論文
    [徐祖安] 期刊論文
    [李靜琪] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB27458013.pdf1954KbAdobe PDF481檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋