國家衛生研究院 NHRI:Item 3990099045/9884
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    题名: Mycotoxin patulin suppresses innate immune responses by mitochondrial dysfunction and p62/sequestosome-1-dependent mitophagy
    作者: Tsai, WT;Lo, YC;Wu, MS;Li, CY;Kuo, YP;Lai, YH;Tsai, Y;Chen, KC;Chuang, TH;Yao, CH;Lee, JC;Hsu, LC;Hsu, JT;Yu, GY
    贡献者: Division of Infectious Diseases;Immunology Research Center;Institute of Biotechnology and Pharmaceutical Research
    摘要: Innate immune responses are important for pathogen elimination and adaptive immune response activation. However, excess inflammation may contribute to immunopathology and disease progression, e.g. inflammation-associated hepatocellular carcinoma. Immune modulation resulting from pattern recognition receptor (PRR)-induced responses is a potential strategy for controlling immunopathology and related diseases. This study demonstrates that the mycotoxin patulin suppresses Toll-like receptor (TLR)- and RIG-I/MAVS-dependent cytokine production through GSH depletion, mitochondrial dysfunction, the activation of p62-associated mitophagy and p62-TRAF6 interaction. Blockade of autophagy restored the immunosuppressive activity of patulin and pharmmacological activation of p62-dependent mitophagy directly reduced RLR-dependent inflammatory cytokine production. These results demonstrated that p62-dependent mitophagy has an immunosuppressive role to innate immune response and might serve as a potential immunomodulatory target for inflammation-associated diseases.
    日期: 2016-09
    關聯: Journal of Biological Chemistry. 2016 Sep;291(37):19299-19311.
    Link to: http://dx.doi.org/10.1074/jbc.M115.686683
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1083-351X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000383242800011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84986877476
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