國家衛生研究院 NHRI:Item 3990099045/9816

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Title:	Total synthesis of the naturally occurring glycosylflavone aciculatin
Authors:	Yao, CH;Tsai, CH;Lee, JC
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	The new flavone-glycoside aciculatin (1), from Chrysopogon aciculatus, has been shown to have cytotoxic, anti-inflammatory, and antiarthritis activity. Further biological studies have been limited because of the limited availability of 1 from natural sources. Herein the first total synthesis of 1 in an overall yield of 8.3% is described. The synthesis involved the regio- and stereoselective glycosylation-Fries-type O-to-C rearrangement to construct the C-aryl glycosidic linkage, followed by a Baker-Venkataraman rearrangement and cyclodehydration to form the flavone scaffold.
Date:	2016-07
Relation:	Journal of Natural Products. 2016 Jul;79(7):1719-1723.
Link to:	http://dx.doi.org/10.1021/acs.jnatprod.5b01051
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0163-3864&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000380422400002
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84979590898
Appears in Collections:	[Jinq-Chyi Lee] Periodical Articles

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