| 2022-11 |
Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone |
Bioorganic Chemistry. 2022 Nov;128:Article number 105905. |
 |
| 2021-08-01 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity |
Life Sciences. 2021 Aug 1;278:Article number 119574. |
|
| 2021-01 |
BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy |
Translational Oncology. 2021 Jan;14(1):Article number 100897. |
|
| 2019-04-01 |
A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus |
European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268. |
|
| 2019-04-01 |
The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone |
European Journal of Medicinal Chemistry. 2019 Apr 1;167:312-323. |
|
| 2019-03 |
Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors |
Bioorganic Chemistry. 2019 Mar;83:520-525. |
|
| 2018-04 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy |
Bioorganic Chemistry. 2018 Apr;77:600-607. |
|
| 2018-01-01 |
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2 |
European Journal of Medicinal Chemistry. 2018 Jan 1;143:611-620. |
|
| 2017-06-22 |
Targeting coronaviral replication and cellular JAK2 mediated dominant NF-kappaB activation for comprehensive and ultimate inhibition of coronaviral activity |
Scientific Reports. 2017 Jun 22;7:Article number 4105. |
|
| 2017-01 |
A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide |
Journal of Medicinal Chemistry. 2017 Jan;60(1):228-247. |
|
| 2016-05 |
N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors |
Bioorganic and Medicinal Chemistry. 2016 May;24(10):2242-2250. |
|
| 2016-01 |
Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy |
Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430. |
|
| 2015-07 |
Development and application of a fluorescent glucose uptake assay for the high-throughput screening of non-glycoside SGLT2 inhibitors |
European Journal of Pharmaceutical Sciences. 2015 Jul;74:40-44. |
|
| 2015-07 |
Pharmacological induction of human fetal globin gene in hydroxyurea-resistant primary adult erythroid cells |
Molecular and Cellular Biology. 2015 Jul;35(14):2541-2553. |
|
| 2015-07 |
Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations |
European Journal of Medicinal Chemistry. 2015 Jul;100:151-161. |
|
| 2015-05 |
A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis |
Diabetes, Obesity and Metabolism. 2015 May;17(5):495-504. |
|
| 2014-12-01 |
Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling |
Nucleic Acids Research. 2014 Dec 1;42(21):13012-13025. |
|
| 2014-09 |
Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists |
Bioorganic and Medicinal Chemistry. 2014 Sep;22(17): 4694-4703. |
|
| 2014-08 |
Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406. |
|
| 2014-08 |
Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells |
Oncotarget. 2014 Aug;5(15):6087-6101. |
|
| 2014-01-08 |
Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer |
PLoS ONE. 2014 Jan 8;9(1):Article number e83160. |
|
| 2013-11-13 |
Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice |
Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933. |
|
| 2013-11 |
BPR0C305, an orally active microtubule-disrupting anticancer agent |
Anticancer Drugs. 2013 Nov;24(10):1047-1057. |
|
| 2013-06-28 |
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor |
Journal of Medicinal Chemistry. 2013 Jun 28;56(13):5247-5260. |
|
| 2013-06 |
c-Jun-mediated anti-cancer mechanisms of tylophorine |
Carcinogenesis. 2013 Jun;34(6):1304-1314. |
|
| 2013-06 |
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry. 2013 Jun;21(11):2856-2867. |
|
| 2013-05 |
Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus |
Antiviral Research. 2013 May;98(2):228-241. |
|
| 2013-05 |
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules |
Proceedings of the National Academy of Sciences of the United States of America. 2013 May;110(19):E1779-E1787. |
|
| 2013-05 |
Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors |
Journal of Medicinal Chemistry. 2013 May;56(10):3889-3903. |
|
| 2013-02 |
Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems |
Antimicrobial Agents and Chemotherapy. 2013 Feb; 57(2):723-733. |
|
| 2013-01 |
3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor |
ChemMedChem. 2013 Jan;8(1):136-148. |
|
| 2012-12-13 |
Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: Exploration of the role of tylophorine e ring on biological activity |
Journal of Medicinal Chemistry. 2012 Dec 13;55(23):10363-10377. |
|
| 2012-12 |
An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold |
Journal of the Chinese Chemical Society. 2012 Dec;59(12):1548-1554. |
|
| 2012-09 |
Anti-influenza drug discovery: Identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization |
ChemMedChem. 2012 Sep;7(9):1546-1550. |
|
| 2012-09 |
Putative tumor metastasis-associated genes in human gastric cancer |
International Journal of Oncology. 2012 Sep;41(3):1068-1084. |
|
| 2012-07 |
Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors |
International Journal of Obesity. 2012 Jul;36(7):999-1006. |
|
| 2012-06-07 |
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry Letters. 2012 Jun 7;22(14):4654-4659. |
|
| 2012-06 |
EGFR and myosin II inhibitors cooperate to suppress EGFR-T790M-mutant NSCLC cells |
Molecular Oncology. 2012 Jun;6(3):299-310. |
|
| 2012-02 |
Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents |
Investigational New Drugs. 2012 Feb;30(1):164-175. |
|
| 2012-02 |
Discovery of novel stem cell mobilizers that target the CXCR4 receptor |
ChemMedChem. 2012 Feb;7(2):209-212. |
|
| 2012-01 |
Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor |
Antimicrobial Agents and Chemotherapy. 2012 Jan;56(1):44-53. |
|
| 2012-01 |
BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML |
British Journal of Cancer. 2012 Jan;106(3):475-481. |
|
| 2012-01 |
A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors |
Anticancer Research. 2012 Jan;32(1):147-151. |
|
| 2011-11 |
Isolation and biological activities of phenanthroindolizidine and septicine alkaloids from the formosan tylophora ovata |
Planta Medica. 2011 Nov;77(17):1932-1938. |
|
| 2011-09 |
Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway |
Journal of Virology. 2011 Sep;85(17):9114-9126 |
|
| 2011-07-25 |
The first total synthesis of cytopiloyne, an anti-diabetic, polyacetylenic glucoside |
Chemistry-A European Journal. 2011 Jul 25;17(31):8696-8703. |
|
| 2011-07 |
Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) |
Bioorganic and Medicinal Chemistry. 2011 Jul;19(14):4173-4182 . |
|
| 2011-06 |
Hot topic: Opportunities and potential challenges for the treatment of metabolic syndrome |
Current Topics In Medicinal Chemistry. 2011 Jun;11(12):1420. |
|
| 2011-04 |
Isatin-beta-thiosemicarbazones as potent herpes simplex virus inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2011 Apr;21(7):1948-1952. |
|
| 2011-03 |
Successful propagation of flavivirus infectious cDNAs by a novel method to reduce the cryptic bacterial promoter activity of virus genomes |
Journal of Virology. 2011 Mar;85(6):2927-2941. |
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