邻近类别 會議論文/會議摘要 [14/24] 專利 [0/8] 类别统计 近3年内发表的文件:18(15.00%) 含全文笔数:119(99.17%) 文件下载次数统计 下载大于0次:119(100.00%) 下载大于100次:114(95.80%) 全文下载总次数:72469(90.20%) 最后更新时间: 2024-12-01 00:24 上传排行 数据加载中..... 下载排行 数据加载中..... 最近上传 DBPR116, a prodrug of BPRMU191, in ... Discovery of a mu-opioid receptor m... Development of a humanized antibody... Discovery of dual MER/AXL kinase in... Discovery of a long half-life AURKA... A dual nociceptin and mu opioid rec... Discovery of tetrasubstituted thiop... Development of furanopyrimidine-bas... 2,6-Difluorobenzamide derivatives a... Protective effect of CXCR4 antagoni...

跳至: (选择年份) 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1985 1980 1975 1970 1960 1950 (选择月份) January February March April May June July August September October November December 或输入年份:

由新到旧排序 由最旧的开始

显示项目1-25 / 120. (共5页) 1 2 3 4 5 > >> 每页显示[10|25|50]项目

日期	题名	關聯
2024-10-29	DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration	Journal of Medicinal Chemistry. 2024 Oct 29;Article in Press.
2024-07-17	Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	Cell Chemical Biology. 2024 Jul 17;Article in Press.
2024-07-04	Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells	Cells. 2024 Jul 04;13(13):Article number 1146.
2024-06-24	Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment	Journal of Medicinal Chemistry. 2024 Jun 24;Article in Press.
2024-06-01	Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus	Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779.
2023-10-05	Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease	European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115583.
2023-10-05	A dual nociceptin and mu opioid receptor agonist exhibited robust antinociceptive effect with decreased side effects	European Journal of Medicinal Chemistry. 2023 Oct 05;258:Article number 115608.
2023-02-07	Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer	Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588.
2022-12-05	Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation	European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728.
2022-12-05	2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors	European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114773.
2022-10-13	Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate	Journal of Medicinal Chemistry. 2022 Oct 13;65(19):12802-12824.
2022-10-03	Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention	International Journal of Molecular Sciences. 2022 Oct 3;23(19):Article number 11730.
2022-07-24	Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice	Journal of Biomedical Science. 2022 Jul 24;29:Article number 53.
2022-07	Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate	Biomedicine and Pharmacotherapy. 2022 Jul;151:Article number 113084.
2022-06-21	Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids	Pharmaceutics. 2022 Jun 21;14(7):Article number 1316.
2022-03-02	Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy	Journal of Medicinal Chemistry. 2022 Mar 2;65(6):4767-4782.
2022-02-15	Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates	Frontiers in Chemistry. 2022 Feb 15;9:Article number 822587.
2022-02-05	Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design	European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
2021-11-15	Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization	European Journal of Medicinal Chemistry. 2021 Nov 15;224:Article number 113673.
2021-10-14	Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model	Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497.
2021-08-01	DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity	Life Sciences. 2021 Aug 1;278:Article number 119574.
2021-05-19	Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins	Journal of Medicinal Chemistry. 2021 May 19;64(11):7312-7330.
2021-03-30	A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment	Proceedings of the National Academy of Sciences of the United States of America. 2021 Mar 30;118(13):Article number e2015433118.
2021-01	Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors	Chemical Biology and Drug Design. 2021 Jan;97(1):51-66.
2021-01	BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy	Translational Oncology. 2021 Jan;14(1):Article number 100897.

显示项目1-25 / 120. (共5页) 1 2 3 4 5 > >> 每页显示[10|25|50]项目