國家衛生研究院 NHRI:Item 3990099045/5248
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    题名: Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening
    作者: Wu, JS;Peng, YH;Wu, JM;Hsieh, CJ;Wu, SH;Coumar, MS;Song, JS;Lee, JC;Tsai, CH;Chen, CT;Liu, YW;Chao, YS;Wu, SY
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: A ligand-based virtual screening strategy (a combination of pharmacophore model generation, shape-based scoring, and structure clustering analysis) was developed to discover novel SGLT2 inhibitors. The best pharmacophore model, generated from eight glycoside inhibitors, was utilized to virtually screen three chemical databases that led to the identification of three non-glycoside SGLT2 inhibitors. This is the first report of the generation of a pharmacophore model from glycosides that has then been used to discover novel non-glycosides hits.
    日期: 2010-12
    關聯: Journal of Medicinal Chemistry. 2010 Dec;53(24):8770-8774.
    Link to: http://dx.doi.org/10.1021/jm101080v
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000285264300030
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650346635
    显示于类别:[陳炯東] 期刊論文
    [伍素瑩] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [李靜琪] 期刊論文

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