國家衛生研究院 NHRI:Item 3990099045/5248

NHRI > Institute of Biotechnology and Pharmaceutical Research > Chiung-Tong Chen > Periodical Articles > Item 3990099045/5248

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5248

Title:	Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening
Authors:	Wu, JS;Peng, YH;Wu, JM;Hsieh, CJ;Wu, SH;Coumar, MS;Song, JS;Lee, JC;Tsai, CH;Chen, CT;Liu, YW;Chao, YS;Wu, SY
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	A ligand-based virtual screening strategy (a combination of pharmacophore model generation, shape-based scoring, and structure clustering analysis) was developed to discover novel SGLT2 inhibitors. The best pharmacophore model, generated from eight glycoside inhibitors, was utilized to virtually screen three chemical databases that led to the identification of three non-glycoside SGLT2 inhibitors. This is the first report of the generation of a pharmacophore model from glycosides that has then been used to discover novel non-glycosides hits.
Date:	2010-12
Relation:	Journal of Medicinal Chemistry. 2010 Dec;53(24):8770-8774.
Link to:	http://dx.doi.org/10.1021/jm101080v
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000285264300030
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650346635
Appears in Collections:	[Chiung-Tong Chen] Periodical Articles [Su-Ying Wu] Periodical Articles [Yu-Sheng Chao(2002-2013)] Periodical Articles [Jinq-Chyi Lee] Periodical Articles

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