國家衛生研究院 NHRI:Item 3990099045/2570
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    題名: Liquid chromatography/tandem mass spectrometric method for the simultaneous determination of tobacco-specific nitrosamine NNK and its five metabolites
    作者: Lee, HL;Wang, CY;Lin, S;Hsieh, DPH
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: A sensitive and robust high-performance liquid chromatography-electrospray ionization tandem mass spectrometry method to analyze 4(methylnitrosamino)-1-(3-pyridyl)-l-butanone (NNK) and its five metabolites in one passage was developed and validated. The method achieved excellent reproducibility and accuracy. Linearity was observed for all six compounds (R-2 = 0.999) with detection limits (S/N >= 3) ranging from 0.2 to 2.4pg on column and 0.01-0.12ngm(-l) in samples injected. Average intra-day and inter-day variations (% R.S.D.) were 1.2 and 3.5%, respectively. A sample preparation method involving C8 and C18 solid phase extraction provided satisfactory recovery of the analytes in mouse urine. Each NNK metabolite was identified by its chromatographic retention time and specific fragmentation pattern. Since the carcinogenicity of NNK is related to its metabolism, the method described in this report should facilitate toxicological investigations into the carcinogenesis due to NNK exposure in the environment. (c) 2007 Elsevier B.V. All rights reserved.
    關鍵詞: Chemistry, Analytical
    日期: 2007-08-15
    關聯: Talanta. 2007 Aug;73(1):76-80.
    Link to: http://dx.doi.org/10.1016/j.talanta.2007.03.001
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0039-9140&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000249174700010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34547136468
    顯示於類別:[謝顯堂(2004-2007)] 期刊論文

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