國家衛生研究院 NHRI:Item 3990099045/2570
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12189/12972 (94%)
造访人次 : 954436      在线人数 : 740
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/2570


    题名: Liquid chromatography/tandem mass spectrometric method for the simultaneous determination of tobacco-specific nitrosamine NNK and its five metabolites
    作者: Lee, HL;Wang, CY;Lin, S;Hsieh, DPH
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: A sensitive and robust high-performance liquid chromatography-electrospray ionization tandem mass spectrometry method to analyze 4(methylnitrosamino)-1-(3-pyridyl)-l-butanone (NNK) and its five metabolites in one passage was developed and validated. The method achieved excellent reproducibility and accuracy. Linearity was observed for all six compounds (R-2 = 0.999) with detection limits (S/N >= 3) ranging from 0.2 to 2.4pg on column and 0.01-0.12ngm(-l) in samples injected. Average intra-day and inter-day variations (% R.S.D.) were 1.2 and 3.5%, respectively. A sample preparation method involving C8 and C18 solid phase extraction provided satisfactory recovery of the analytes in mouse urine. Each NNK metabolite was identified by its chromatographic retention time and specific fragmentation pattern. Since the carcinogenicity of NNK is related to its metabolism, the method described in this report should facilitate toxicological investigations into the carcinogenesis due to NNK exposure in the environment. (c) 2007 Elsevier B.V. All rights reserved.
    关键词: Chemistry, Analytical
    日期: 2007-08-15
    關聯: Talanta. 2007 Aug;73(1):76-80.
    Link to: http://dx.doi.org/10.1016/j.talanta.2007.03.001
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0039-9140&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000249174700010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34547136468
    显示于类别:[謝顯堂(2004-2007)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    000249174700010.pdf149KbAdobe PDF1189检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈