| 2022-02-05 |
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design |
European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043. |
 |
| 2021-08-12 |
Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) |
Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301. |
|
| 2020-02-10 |
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors |
Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659. |
|
| 2019-12 |
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia |
Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150. |
|
| 2019-11-27 |
Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer |
Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123. |
|
| 2019-10 |
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer |
Annals of Oncology. 2019 Oct;30(Suppl. 5):789. |
|
| 2019-04-10 |
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants |
Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957. |
|
| 2018-04 |
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy |
Bioorganic Chemistry. 2018 Apr;77:600-607. |
|
| 2017-06 |
Mutagenesis of dengue virus protein NS2A revealed a novel domain responsible for virus-induced cytopathic effect and interactions between NS2A and NS2B transmembrane segments |
Journal of Virology. 2017 Jun;91(12):Article number e01836-16. |
|
| 2016-12 |
Phenyl benzenesulfonylhydrazides: Selective indoleamine 2,3-dioxygenase inhibitors with potent in vivo pharmacodynamic activity and antitumor efficacy |
European Journal of Cancer. 2016 Dec;68(Suppl. 1):S83-S84. |
|
| 2016-04-12 |
Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK) |
Journal of Medicinal Chemistry. 2016 Apr 12;59(8):3906-3919. |
|
| 2016-01 |
Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1 |
Journal of Medicinal Chemistry. 2016 Jan;59 (1):282-293. |
|
| 2016-01 |
Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy |
Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430. |
|
| 2015-10 |
Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening |
Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819. |
|
| 2015-07-31 |
作為極光激酶抑制劑的稠合雙環嘧啶化合物 |
HK1151694/2015-07-31 |
|
| 2014-10-29 |
作為極光激酶抑制劑的稠合雙環嘧啶化合物 |
ZL200980115577.4/2014-10-29 |
|
| 2014-08 |
Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors |
Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406. |
|
| 2014-03-20 |
Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
JP5502072/2014-03-20 |
|
| 2013-09 |
Furanylazaindoles: Potent anticancer agents in vitro and in vivo |
Journal of Medicinal Chemistry. 2013 Sep;56(20):8008-8018. |
|
| 2013-05 |
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules |
Proceedings of the National Academy of Sciences of the United States of America. 2013 May;110(19):E1779-E1787. |
|
| 2013-05 |
Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors |
Journal of Medicinal Chemistry. 2013 May;56(10):3889-3903. |
|
| 2013-02 |
Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems |
Antimicrobial Agents and Chemotherapy. 2013 Feb; 57(2):723-733. |
|
| 2012-08 |
Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching |
Analytical Chemistry. 2012 Aug;84(15):6391-6399. |
|
| 2012-06 |
Involvement of transcriptional regulator Ndt80 in stress responses of Candida albicans |
Mycoses. 2012 Jun;55(Suppl. S4):131-132. |
|
| 2012-05-11 |
作為極光激酶抑制劑之稠合雙環嘧啶化合物 |
I363627/2012-05-11 |
|
| 2012-03-20 |
Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
US8138194B2/2012-03-20 |
|
| 2012-02 |
Discovery of novel stem cell mobilizers that target the CXCR4 receptor |
ChemMedChem. 2012 Feb;7(2):209-212. |
|
| 2012-01-17 |
Pyrrolidine compounds |
CA2559611/2012-01-17 |
|
| 2011-09 |
Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents |
European Journal of Medicinal Chemistry. 2011 Sep;46(9):3623-3629. |
|
| 2011-04-28 |
Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-Fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents |
Journal of Medicinal Chemistry. 2011 Apr 28;54(8):3076-3080. |
|
| 2010-12 |
Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening |
Journal of Medicinal Chemistry. 2010 Dec;53(24):8770-8774. |
|
| 2010-10-06 |
吡咯烷化合物 |
ZL200580009891.6/2010-10-06 |
|
| 2010-10 |
Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists |
ChemMedChem. 2010 Oct;5(10):1707-1716. |
|
| 2010-09 |
Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes |
PLoS ONE. 2010 Sep;5(9):Article number e12564. |
|
| 2010-08 |
Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models |
Abstracts of Papers - American Chemical Society. 2010 Aug;240:MEDI 332. |
|
| 2010-06-15 |
Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification |
Journal of Medicinal Chemistry. 2010 Jun 15;53(13):4980-4988. |
|
| 2010-03-30 |
Pyrrolidine compounds |
US7687504B2/2010-03-30 |
|
| 2010-03-11 |
5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors |
Journal of Medicinal Chemistry. 2010 Mar 11;53(5):2309-2313. |
|
| 2010-02-01 |
Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor |
ChemMedChem. 2010 Feb 1;5(2):255-267. |
|
| 2009-10 |
(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases |
Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055. |
|
| 2009-08-13 |
Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach |
Journal of Medicinal Chemistry. 2009 Aug 13;52(15):4941-4945. |
|
| 2009-07-23 |
Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity |
Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4221-4233. |
|
| 2009-06 |
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.] |
European Journal of Medicinal Chemistry. 2009 Jun;44(6):2763-2763. |
|
| 2009-04-23 |
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists |
Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622. |
|
| 2009-03 |
Discovery and development of novel furano-pyrimidine analogs as Aurora kinase inhibitors |
Abstracts of Papers - American Chemical Society. 2009 Mar;237:MEDI 221. |
|
| 2009-02-26 |
Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity |
Journal of Medicinal Chemistry. 2009 Feb 26;52(4):1050-1062. |
|
| 2009-01-22 |
Pyrrolidine compounds |
AU2005221678/2009-01-22 |
|
| 2008-12-25 |
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents |
Journal of Medicinal Chemistry. 2008 Dec 25;51(24):8163-8167. |
|
| 2008-08 |
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors |
European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611. |
|
| 2008-07-21 |
吡咯啉啶化合物 |
I299039/2008-07-21 |
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