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日期	题名	關聯
2016-03	Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: The impact of P1-variation	MedChemComm. 2016 Mar;7(3):433-438.
2014-06-09	EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog	PLoS ONE. 2014 Jun 9;9(6):Article number e92164.
2014-02	Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum	Journal of Biological Chemistry. 2014 Feb 14;289 (7):4444-4454.
2014-02	Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation	PLoS ONE. 2014 Feb 13;9(2):Article number e88772.
2013-08	Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum	Journal of Biological Chemistry. 2013 Aug;288(35):25330-25339.
2013-02-11	吡咯啶化合物	I385171/2013-02-11
2012-01-17	Pyrrolidine compounds	CA2559611/2012-01-17
2011-12-06	Pyrrolidine compounds	US8071787B2/2011-12-06
2011-11-04	Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9	FEBS Letters. 2011 Nov 4;585(21):3409-3414.
2011-09	Proline in transmembrane domain of type II protein DPP-IV governs Its translocation behavior through endoplasmic reticulum	Biochemistry. 2011 Sep;50(37):7909-7918.
2011-08	Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): Is DPP8-selectivity an attainable goal?	Journal of Medicinal Chemistry. 2011 Aug;54(16):5737-5746.
2011-06	Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate	Journal of Biochemistry. 2011 Jun;149(6):685-692.
2011-03	Processing and turnover of the Hedgehog protein in the endoplasmic reticulum	Journal of Cell Biology. 2011 Mar;192(5):825-838.
2010-12-01	吲哚化合物	ZL200480034988.8/2010-12-01
2010-12	Downregulation of signaling-active IGF-1 by dipeptidyl peptidase IV (DPP-IV)	International Journal of Biomedical Science. 2010 Dec;6(4):301-309.
2010-10-06	吡咯烷化合物	ZL200580009891.6/2010-10-06
2010-10	Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists	ChemMedChem. 2010 Oct;5(10):1707-1716.
2010-09	The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities	Protein Science. 2010 Sep;19(9):1627-1638.
2010-08	Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein	Journal of Medicinal Chemistry. 2010 Aug;53(18):6572-6583.
2010-06-15	(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV	Bioorganic and Medicinal Chemistry Letters. 2010 Jun 15;20(12):3596-3600.
2010-03-30	Pyrrolidine compounds	US7687504B2/2010-03-30
2009-10	(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases	Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055.
2009-09-03	Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis	FEBS Letters. 2009 Sep 3;583(17):2765-2771.
2009-07-15	Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor	Biochemical Pharmacology. 2009 Jul 15;78(2):203-210.
2009-06	Enzyme Activity and Immunohistochemical Localization of Dipeptidyl Peptidase 8 and 9 in Male Reproductive Tissues	Journal of Histochemistry and Cytochemistry. 2009 Jun;57(6):531-541.
2009-06	A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.]	European Journal of Medicinal Chemistry. 2009 Jun;44(6):2763-2763.
2009-05-15	Biochemical properties and expression profile of human prolyl dipeptidase DPP9	Archives of Biochemistry and Biophysics. 2009 May 15;485(2):120-127.
2009-04-23	Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists	Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622.
2009-04-01	Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors	Bioorganic and Medicinal Chemistry Letters. 2009 Apr 1;19(7):1908-1912.
2009-03-15	Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors	Bioorganic and Medicinal Chemistry. 2009 Mar 15;17(6):2388-2399.
2009-01-22	Pyrrolidine compounds	AU2005221678/2009-01-22
2009	Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme	Antiviral Chemistry and Chemotherapy. 2009;19(4):151-156.
2008-12-11	吲哚化合物	I304066/2008-12-11
2008-11-11	Indole compounds	US7449478B2/2008-11-11
2008-08	A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors	European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.
2008-07-21	吡咯啉啶化合物	I299039/2008-07-21
2008-07-15	Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: Identification of dipeptide derived leads	Bioorganic and Medicinal Chemistry Letters. 2008 Jul;18(14):4154-4158.
2008-07-15	Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors	Bioorganic and Medicinal Chemistry Letters. 2008 Jul;18(14):4159-4162.
2008-07-01	Pyrrolidine compounds	KR10-0844593/2008-07-01
2008-05-01	Purification and characterization of a dipeptidyl peptidase 9-like enzyme from bovine testes	Frontiers in Bioscience. 2008 May 1;13(9):3558-3568.
2008-05	Bioassay-guided purification and identification of PPARa/gamma agonists from Chlorella sorokiniana	Phytotherapy Research. 2008 May;22(5):605-613.
2008-04-15	Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus	Biochemical Pharmacology. 2008 Apr;75(8):1601-1609.
2008-04-06	COMP 266-Structure, function and inhibitors of prolyl dipeptidase DPP8	Abstracts of Papers - American Chemical Society. 2008 Apr 6;235:266-COMP.
2007-11-15	Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates	Journal of Medicinal Chemistry. 2007 Nov;50(23):5568-5570.
2007-05	Dipeptidyl peptidase 8/9-like activity in human leukocytes	Journal of Leukocyte Biology. 2007 May;81(5):1252-1257.
2007-03-01	3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes	Bioorganic and Medicinal Chemistry Letters. 2007 Mar;17(5):1274-1279.
2006-12-15	Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8	Journal of Biological Chemistry. 2006 Dec;281(50):38653-38662.
2006-12	Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8	Advances in Experimental Medicine and Biology. 2006 Dec;575:27-32.
2006-10-19	Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists	Journal of Medicinal Chemistry. 2006 Oct;49(21):6421-6424.
2006-09	MEDI 416-3- 2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino -3-methyl-butyr amide analogs as DPP-IV inhibitors for the treatment of type-II diabetes	Abstracts of Papers - American Chemical Society. 2006 Sep;232:MEDI 416.

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