國家衛生研究院 NHRI:Item 3990099045/14966
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    題名: A convenient diels-alder approach toward potential polyketide-like antibiotics using alpha-activated alpha,Beta-unsaturated 4,4-dimethyl-1-tetralones as dienophiles
    其他題名: A convenient diels-alder approach toward potential polyketide-like antibiotics using α-activated α,β-unsaturated 4,4-dimethyl-1-tetralones as dienophiles
    作者: Lee, CJ;Ramasamy, M;Kuan, HH;Wu, CH;Lee, CC;Lee, JC;Shia, KS
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Making use of a Diels–Alder approach based on various α,β-unsaturated 2-carbomethoxy-4,4-dimethyl-1-tetralones as novel dienophiles, the corresponding polycyclic adducts could be efficiently synthesized in good to high yields (74~99%) in the presence of Lewis acid (e.g., SnCl4). Accordingly, a synthetically useful platform is established to provide a focused aromatic polyketide-like library for screening of potential natural and non-natural antimicrobial agents.
    日期: 2023-03-17
    關聯: Molecules. 2023 Mar 17;28(6):Article number 2739.
    Link to: http://dx.doi.org/10.3390/molecules28062739
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1420-3049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000968275900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85151112366
    顯示於類別:[夏克山] 期刊論文
    [李靜琪] 期刊論文

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