國家衛生研究院 NHRI:Item 3990099045/14966

NHRI > Institute of Biotechnology and Pharmaceutical Research > Kak-Shan Shia > Periodical Articles > Item 3990099045/14966

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14966

Title:	A convenient diels-alder approach toward potential polyketide-like antibiotics using alpha-activated alpha,Beta-unsaturated 4,4-dimethyl-1-tetralones as dienophiles
Other Titles:	A convenient diels-alder approach toward potential polyketide-like antibiotics using α-activated α,β-unsaturated 4,4-dimethyl-1-tetralones as dienophiles
Authors:	Lee, CJ;Ramasamy, M;Kuan, HH;Wu, CH;Lee, CC;Lee, JC;Shia, KS
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Making use of a Diels–Alder approach based on various α,β-unsaturated 2-carbomethoxy-4,4-dimethyl-1-tetralones as novel dienophiles, the corresponding polycyclic adducts could be efficiently synthesized in good to high yields (74~99%) in the presence of Lewis acid (e.g., SnCl4). Accordingly, a synthetically useful platform is established to provide a focused aromatic polyketide-like library for screening of potential natural and non-natural antimicrobial agents.
Date:	2023-03-17
Relation:	Molecules. 2023 Mar 17;28(6):Article number 2739.
Link to:	http://dx.doi.org/10.3390/molecules28062739
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1420-3049&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000968275900001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85151112366
Appears in Collections:	[Kak-Shan Shia] Periodical Articles [Jinq-Chyi Lee] Periodical Articles

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