國家衛生研究院 NHRI:Item 3990099045/9664
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    题名: Longitudinal pattern of multiplexed immunoglobulin E Sensitization from prenatal stage to the first year of life
    作者: Wang, JY;Chen, CA;Hou, YI;Hsiao, WL;Huang, YW;Tsai, YT;Tsai, HJ
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: BACKGROUND: The longitudinal pattern of allergen-specific IgE levels from the prenatal stage to early life has remained largely unexplored. METHODS: One hundred and three mother-infant pairs, which were part of an ongoing population-based prospective birth cohort study of early childhood allergic diseases in Tainan, Taiwan, were included in this study. We examined the relationship of 20 allergen-specific IgE levels with blood samples of mothers, cord blood and infants at 12 months of age using Spearman rank correlation, Kenal tau and McNemar test, respectively. RESULTS: Certain degree of IgE sensitization against most 20 examined specific allergens was observed in blood samples of mothers, cord blood and infants at 12 months of age. When we further examined the association between allergic related risk factors and atopy in infants at the first year of life, we found positive association between colic pain and atopy in infants at 12 months of age (adjusted odds ratios (AOR)=3.51; 95% confidence interval (CI): 1.13-10.96; p=0.03), and borderline significance between wheezing and atopy in infants at 12 months of age (AOR=4.58; 95% CI: 0.89-23.50; p=0.07). CONCLUSION: The findings from this study suggest that influence of maternal allergen-specific IgE levels on infant immune response might occur at birth and then wane in infants at 12 months of age. Positive association of colic pain and wheezing with atopy in infants at 12 months of age provide supportive evidence for the "Allergy March" theory of allergy development in an Asian birth cohort.
    日期: 2016-09
    關聯: Pediatric Allergy and Immunology. 2016 Sep ;27(6):620-626.
    Link to: http://dx.doi.org/10.1111/pai.12583
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0905-6157&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000387409000009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84983320061
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