國家衛生研究院 NHRI:Item 3990099045/9664
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 923037      線上人數 : 1027
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9664


    題名: Longitudinal pattern of multiplexed immunoglobulin E Sensitization from prenatal stage to the first year of life
    作者: Wang, JY;Chen, CA;Hou, YI;Hsiao, WL;Huang, YW;Tsai, YT;Tsai, HJ
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: BACKGROUND: The longitudinal pattern of allergen-specific IgE levels from the prenatal stage to early life has remained largely unexplored. METHODS: One hundred and three mother-infant pairs, which were part of an ongoing population-based prospective birth cohort study of early childhood allergic diseases in Tainan, Taiwan, were included in this study. We examined the relationship of 20 allergen-specific IgE levels with blood samples of mothers, cord blood and infants at 12 months of age using Spearman rank correlation, Kenal tau and McNemar test, respectively. RESULTS: Certain degree of IgE sensitization against most 20 examined specific allergens was observed in blood samples of mothers, cord blood and infants at 12 months of age. When we further examined the association between allergic related risk factors and atopy in infants at the first year of life, we found positive association between colic pain and atopy in infants at 12 months of age (adjusted odds ratios (AOR)=3.51; 95% confidence interval (CI): 1.13-10.96; p=0.03), and borderline significance between wheezing and atopy in infants at 12 months of age (AOR=4.58; 95% CI: 0.89-23.50; p=0.07). CONCLUSION: The findings from this study suggest that influence of maternal allergen-specific IgE levels on infant immune response might occur at birth and then wane in infants at 12 months of age. Positive association of colic pain and wheezing with atopy in infants at 12 months of age provide supportive evidence for the "Allergy March" theory of allergy development in an Asian birth cohort.
    日期: 2016-09
    關聯: Pediatric Allergy and Immunology. 2016 Sep ;27(6):620-626.
    Link to: http://dx.doi.org/10.1111/pai.12583
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0905-6157&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000387409000009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84983320061
    顯示於類別:[蔡慧如] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB27089848.pdf495KbAdobe PDF363檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋