國家衛生研究院 NHRI:Item 3990099045/9628
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    题名: Increased levels of oxidative stress biomarkers in metal oxides nanomaterial-handling workers
    作者: Liou, SH;Chen, YC;Liao, HY;Wang, CJ;Chen, JS;Lee, HL
    贡献者: National Institute of Environmental Health Sciences
    摘要: This study assessed oxidatively damaged DNA and antioxidant enzyme activity in workers occupational exposure to metal oxides nanomaterials. Exposure to TiO2, SiO2, and ITO resulted in significant lower antioxidant enzymes (glutathione peroxidase and superoxide dismutase) and higher oxidative biomarkers 8-hydroxydeoxyguanosine (8-oxodG) than comparison workers. Statistically significant correlations were noted between plasma and urine 8-oxodG, between white blood cells (WBC) and urine 8-oxodG, and between WBC and plasma 8-oxodG. In addition, there were significant negative correlations between WBC 8-oxodG and SOD and between urinary 8-oxodG and GPx levels. The results showed that urinary 8-oxodG may be considered to be better biomarker.
    日期: 2016-11
    關聯: Biomarkers. 2016 Nov;21(7):600-606.
    Link to: http://dx.doi.org/10.3109/1354750x.2016.1160432
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1354-750X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000385399600004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84961392278
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