國家衛生研究院 NHRI:Item 3990099045/9112
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    题名: Indole compounds
    作者: Hsieh, HP;Liou, JP;Chang, JY;Chang, CW
    贡献者: Institute of Biotechnology and Pharmaceutical Research;National Institute of Cancer Research
    摘要: Indole compounds of the formula: | | wherein L | | 1 | is CO; L | 2 | is a bond; R | 1 | is aryl or heteroaryl; R | 2 | is H, aryl, heteroaryl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO | 2 | R, SO | 3 | R, SO | 2 | NRR', SR, NRR', NRSO | 2 | NR'R", NRSO | 2 | R', NRSO | 3 | R', NRC(O)R', NRC(O)NR'R", NRC(O)OR', NRC(N)NR'R", C(O)OR, or C(O)NRR'; each of R | a | , R | b | , R | c | , and R | d | , independently, is R, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO | 2 | R, SO | 3 | R, SO | 2 | NRR', SR, NRR', NRSO | 2 | NR'R", NRSO | 2 | R', NRSO | 3 | R', NRC(O)R', NRC(O)NR'R", NRC(O)OR', NRC(N)NR'R", C(O)R, C(O)OR, C(O)NRR', or R | b | and R | c | , R | a | and R | b | , or R | c | and R | d | taken together are O(CH | 2 | ) | n | O; and R | c | is H, alkyl, alkenyl, alkynyl, cyclyl, heterocyclyl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO | 2 | R, SO | 3 | R, SO | 2 | NRR', SR, NRR', NRSO | 2 | NR'R", NRSO | 2 | R', NRSO | 3 | R', NRC(O)R', NRC(O)NR'R", NRC(O)OR', NRC(N)NR'R", C(O)R, C(O)OR, or C(O)NRR'; in which each of R, R', and R", independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, or heterocyclyl; and n is 1, 2, 3, 4, or 5. | Indole compounds of the formula: wherein L<SUB>1 </SUB>is CO; L<SUB>2 </SUB>is a bond; R<SUB>1 </SUB>is aryl or heteroaryl; R<SUB>2 </SUB>is H, aryl, heteroaryl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO<SUB>2</SUB>R, SO<SUB>3</SUB>R, SO<SUB>2</SUB>NRR', SR, NRR', NRSO<SUB>2</SUB>NR'R'', NRSO<SUB>2</SUB>R', NRSO<SUB>3</SUB>R', NRC(O)R', NRC(O)NR'R'', NRC(O)OR', NRC(N)NR'R'', C(O)OR, or C(O)NRR'; each of R<SUB>a</SUB>, R<SUB>b</SUB>, R<SUB>c</SUB>, and R<SUB>d</SUB>, independently, is R, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO<SUB>2</SUB>R, SO<SUB>3</SUB>R, SO<SUB>2</SUB>NRR', SR, NRR', NRSO<SUB>2</SUB>NR'R'', NRSO<SUB>2</SUB>R', NRSO<SUB>3</SUB>R', NRC(O)R', NRC(O)NR'R'', NRC(O)OR', NRC(N)NR'R'', C(O)R, C(O)OR, C(O)NRR', or R<SUB>b </SUB>and R<SUB>c</SUB>, R<SUB>a </SUB>and R<SUB>b</SUB>, or R<SUB>c </SUB>and R<SUB>d </SUB>taken together are O(CH<SUB>2</SUB>)<SUB>n</SUB>O; and R<SUB>c </SUB>is H, alkyl, alkenyl, alkynyl, cyclyl, heterocyclyl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO<SUB>2</SUB>R, SO<SUB>3</SUB>R, SO<SUB>2</SUB>NRR', SR, NRR', NRSO<SUB>2</SUB>NR'R'', NRSO<SUB>2</SUB>R', NRSO<SUB>3</SUB>R', NRC(O)R', NRC(O)NR'R'', NRC(O)OR', NRC(N)NR'R'', C(O)R, C(O)OR, or C(O)NRR'; in which each of R, R', and R'', independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, or heterocyclyl; and n is 1, 2, 3, 4, or 5.
    日期: 2005-08-23
    關聯: US6933316B2/2005-08-23
    Link to: http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=6933316&KC=B2
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