國家衛生研究院 NHRI:Item 3990099045/9112

NHRI > Institute of Biotechnology and Pharmaceutical Research > Hsing-Pang Hsieh > Patents > Item 3990099045/9112

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9112

Title:	Indole compounds
Authors:	Hsieh, HP;Liou, JP;Chang, JY;Chang, CW
Contributors:	Institute of Biotechnology and Pharmaceutical Research;National Institute of Cancer Research
Abstract:	Indole compounds of the formula: \| \| wherein L \| \| 1 \| is CO; L \| 2 \| is a bond; R \| 1 \| is aryl or heteroaryl; R \| 2 \| is H, aryl, heteroaryl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO \| 2 \| R, SO \| 3 \| R, SO \| 2 \| NRR', SR, NRR', NRSO \| 2 \| NR'R", NRSO \| 2 \| R', NRSO \| 3 \| R', NRC(O)R', NRC(O)NR'R", NRC(O)OR', NRC(N)NR'R", C(O)OR, or C(O)NRR'; each of R \| a \| , R \| b \| , R \| c \| , and R \| d \| , independently, is R, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO \| 2 \| R, SO \| 3 \| R, SO \| 2 \| NRR', SR, NRR', NRSO \| 2 \| NR'R", NRSO \| 2 \| R', NRSO \| 3 \| R', NRC(O)R', NRC(O)NR'R", NRC(O)OR', NRC(N)NR'R", C(O)R, C(O)OR, C(O)NRR', or R \| b \| and R \| c \| , R \| a \| and R \| b \| , or R \| c \| and R \| d \| taken together are O(CH \| 2 \| ) \| n \| O; and R \| c \| is H, alkyl, alkenyl, alkynyl, cyclyl, heterocyclyl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO \| 2 \| R, SO \| 3 \| R, SO \| 2 \| NRR', SR, NRR', NRSO \| 2 \| NR'R", NRSO \| 2 \| R', NRSO \| 3 \| R', NRC(O)R', NRC(O)NR'R", NRC(O)OR', NRC(N)NR'R", C(O)R, C(O)OR, or C(O)NRR'; in which each of R, R', and R", independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, or heterocyclyl; and n is 1, 2, 3, 4, or 5. \| Indole compounds of the formula: wherein L<SUB>1 </SUB>is CO; L<SUB>2 </SUB>is a bond; R<SUB>1 </SUB>is aryl or heteroaryl; R<SUB>2 </SUB>is H, aryl, heteroaryl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO<SUB>2</SUB>R, SO<SUB>3</SUB>R, SO<SUB>2</SUB>NRR', SR, NRR', NRSO<SUB>2</SUB>NR'R'', NRSO<SUB>2</SUB>R', NRSO<SUB>3</SUB>R', NRC(O)R', NRC(O)NR'R'', NRC(O)OR', NRC(N)NR'R'', C(O)OR, or C(O)NRR'; each of R<SUB>a</SUB>, R<SUB>b</SUB>, R<SUB>c</SUB>, and R<SUB>d</SUB>, independently, is R, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO<SUB>2</SUB>R, SO<SUB>3</SUB>R, SO<SUB>2</SUB>NRR', SR, NRR', NRSO<SUB>2</SUB>NR'R'', NRSO<SUB>2</SUB>R', NRSO<SUB>3</SUB>R', NRC(O)R', NRC(O)NR'R'', NRC(O)OR', NRC(N)NR'R'', C(O)R, C(O)OR, C(O)NRR', or R<SUB>b </SUB>and R<SUB>c</SUB>, R<SUB>a </SUB>and R<SUB>b</SUB>, or R<SUB>c </SUB>and R<SUB>d </SUB>taken together are O(CH<SUB>2</SUB>)<SUB>n</SUB>O; and R<SUB>c </SUB>is H, alkyl, alkenyl, alkynyl, cyclyl, heterocyclyl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR, OC(O)R, OC(O)OR, OC(O)NRR', SO<SUB>2</SUB>R, SO<SUB>3</SUB>R, SO<SUB>2</SUB>NRR', SR, NRR', NRSO<SUB>2</SUB>NR'R'', NRSO<SUB>2</SUB>R', NRSO<SUB>3</SUB>R', NRC(O)R', NRC(O)NR'R'', NRC(O)OR', NRC(N)NR'R'', C(O)R, C(O)OR, or C(O)NRR'; in which each of R, R', and R'', independently, is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, or heterocyclyl; and n is 1, 2, 3, 4, or 5.
Date:	2005-08-23
Relation:	US6933316B2/2005-08-23
Link to:	http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=6933316&KC=B2
Appears in Collections:	[Hsing-Pang Hsieh] Patents [Jang-Yang Chang] Patents

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