國家衛生研究院 NHRI:Item 3990099045/8889
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 861774      線上人數 : 763
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8889


    題名: Pentoxifylline decreases dialysis risk in patients with advanced cronic kidney disease
    作者: Wu, PC;Wu, CJ;Lin, CJ;Pan, CF;Chen, CY;Huang, TM;Wu, CH;Lin, SL;Chen, YM;Chen, L;Wu, VC
    貢獻者: Division of Health Services and Preventive Medicine
    摘要: Few studies evaluated the effects of pentoxifylline on hard endpoints in patients with predialysis stage 5 chronic kidney disease (CKD). We thus tried to explore the effects of pentoxifylline and its interaction with renin-angiotensin-aldosterone system (RAAS) blockade on the development of end-stage renal disease (ESRD) and mortality. This nationwide cohort study retrospectively included patients who had a serum creatinine level of > 6 mg/dL and received erythropoiesis-stimulating agents between 2000 and 2010. We analyzed 7,366 pentoxifylline users and 7,366 propensity score-matched nonusers. Using Cox proportional hazard models, pentoxifylline reduced the risks of ESRD and the composite renal outcome but not that of mortality. In terms of the risks of developing ESRD, pentoxifylline alone exerted a comparable beneficial effect to combined therapy with an RAAS inhibitor and greater renoprotection than RAAS inhibitor monotherapy. This study suggests pentoxifylline is efficacious in slowing progression to ESRD in patients with predialysis stage 5 CKD.
    日期: 2015-10
    關聯: Clinical Pharmacology and Therapeutics. 2015 Oct;98(4):442-449.
    Link to: http://dx.doi.org/10.1002/cpt.173
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-9236&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000363405200026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84952759707
    顯示於類別:[陳麗光] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB26082272.pdf299KbAdobe PDF360檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋