國家衛生研究院 NHRI:Item 3990099045/8889
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8889


    Title: Pentoxifylline decreases dialysis risk in patients with advanced cronic kidney disease
    Authors: Wu, PC;Wu, CJ;Lin, CJ;Pan, CF;Chen, CY;Huang, TM;Wu, CH;Lin, SL;Chen, YM;Chen, L;Wu, VC
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: Few studies evaluated the effects of pentoxifylline on hard endpoints in patients with predialysis stage 5 chronic kidney disease (CKD). We thus tried to explore the effects of pentoxifylline and its interaction with renin-angiotensin-aldosterone system (RAAS) blockade on the development of end-stage renal disease (ESRD) and mortality. This nationwide cohort study retrospectively included patients who had a serum creatinine level of > 6 mg/dL and received erythropoiesis-stimulating agents between 2000 and 2010. We analyzed 7,366 pentoxifylline users and 7,366 propensity score-matched nonusers. Using Cox proportional hazard models, pentoxifylline reduced the risks of ESRD and the composite renal outcome but not that of mortality. In terms of the risks of developing ESRD, pentoxifylline alone exerted a comparable beneficial effect to combined therapy with an RAAS inhibitor and greater renoprotection than RAAS inhibitor monotherapy. This study suggests pentoxifylline is efficacious in slowing progression to ESRD in patients with predialysis stage 5 CKD.
    Date: 2015-10
    Relation: Clinical Pharmacology and Therapeutics. 2015 Oct;98(4):442-449.
    Link to: http://dx.doi.org/10.1002/cpt.173
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-9236&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000363405200026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84952759707
    Appears in Collections:[Li-Kwang Chen] Periodical Articles

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