國家衛生研究院 NHRI:Item 3990099045/8879
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 860730      線上人數 : 864
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版
    國家衛生研究院 NHRI > 癌症研究所 > 其他 > 期刊論文 >  Item 3990099045/8879


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8879


    題名: PTP4A3 independently predicts metastasis and survival in upper tract urothelial carcinoma treated with radical nephroureterectomy
    作者: Yeh, HC;Li, CC;Huang, CN;Hour, TC;Yeh, BW;Li, WM;Liang, PI;Chang, LL;Li, CF;Wu, WJ
    貢獻者: National Institute of Cancer Research
    摘要: AbstractPurpose Increasing evidence has shown that protein tyrosine phosphatases play dominant roles in setting the levels of tyrosine phosphorylation and promote oncogenic processes. Protein tyrosine phosphatase type IVA 3 (PTP4A3) has been implicated in cancer metastasis, however the role of PTP4A3 in upper tract urothelial carcinoma (UTUC) is unknown. The aim of this study was to investigate the association of PTP4A3 with disease characteristics, distant metastasis, and prognosis of UTUC. Materials and methods The importance of PTP4A3 was initially examined in paired normal urothelium, non-invasive UTUC, invasive UTUC, and nodal metastatic tissue. The PTP4A3 transcript level was assessed in another 20 UTUC samples by real-time RT-PCR. PTP4A3 protein expression was determined by immunohistochemistry (H-score) in 340 UTUC samples, and further correlated with clinicopathological factors, disease-specific survival and metastasis-free survival. Results The expression of PTP4A3 significantly increased from normal urothelium, non-invasive UTUC, invasive UTUC, to nodal metastatic tissue (p <0.001). The PTP4A3 transcript level was also markedly upregulated in higher stage UTUC (p = 0.002). The overexpression of PTP4A3 protein was significantly associated with advanced pT status, nodal metastasis, lymphovascular invasion, and perineural invasion (all p <0.001), and an inferior disease-specific survival and metastasis-free survival in multivariate analysis (both p <0.0001). In addition, it predicted metastasis in patients with pTa, pT1, and pT2 UTUC. Conclusions The results imply that PTP4A3 plays a role in the carcinogenesis of UTUC. PTP4A3 overexpression independently predicted metastasis and outcome of UTUC, which was even more important in organ-confined disease.
    日期: 2015-11
    關聯: Journal of Urology. 2015 Nov;194(5):1449-1455.
    Link to: http://dx.doi.org/10.1016/j.juro.2015.05.101
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-5347&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000366011100017
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84943644457
    顯示於類別:[其他] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SDO0022534715041518.pdf1892KbAdobe PDF373檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋