國家衛生研究院 NHRI:Item 3990099045/8879
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    题名: PTP4A3 independently predicts metastasis and survival in upper tract urothelial carcinoma treated with radical nephroureterectomy
    作者: Yeh, HC;Li, CC;Huang, CN;Hour, TC;Yeh, BW;Li, WM;Liang, PI;Chang, LL;Li, CF;Wu, WJ
    贡献者: National Institute of Cancer Research
    摘要: AbstractPurpose Increasing evidence has shown that protein tyrosine phosphatases play dominant roles in setting the levels of tyrosine phosphorylation and promote oncogenic processes. Protein tyrosine phosphatase type IVA 3 (PTP4A3) has been implicated in cancer metastasis, however the role of PTP4A3 in upper tract urothelial carcinoma (UTUC) is unknown. The aim of this study was to investigate the association of PTP4A3 with disease characteristics, distant metastasis, and prognosis of UTUC. Materials and methods The importance of PTP4A3 was initially examined in paired normal urothelium, non-invasive UTUC, invasive UTUC, and nodal metastatic tissue. The PTP4A3 transcript level was assessed in another 20 UTUC samples by real-time RT-PCR. PTP4A3 protein expression was determined by immunohistochemistry (H-score) in 340 UTUC samples, and further correlated with clinicopathological factors, disease-specific survival and metastasis-free survival. Results The expression of PTP4A3 significantly increased from normal urothelium, non-invasive UTUC, invasive UTUC, to nodal metastatic tissue (p <0.001). The PTP4A3 transcript level was also markedly upregulated in higher stage UTUC (p = 0.002). The overexpression of PTP4A3 protein was significantly associated with advanced pT status, nodal metastasis, lymphovascular invasion, and perineural invasion (all p <0.001), and an inferior disease-specific survival and metastasis-free survival in multivariate analysis (both p <0.0001). In addition, it predicted metastasis in patients with pTa, pT1, and pT2 UTUC. Conclusions The results imply that PTP4A3 plays a role in the carcinogenesis of UTUC. PTP4A3 overexpression independently predicted metastasis and outcome of UTUC, which was even more important in organ-confined disease.
    日期: 2015-11
    關聯: Journal of Urology. 2015 Nov;194(5):1449-1455.
    Link to: http://dx.doi.org/10.1016/j.juro.2015.05.101
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-5347&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000366011100017
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84943644457
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