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http://ir.nhri.org.tw/handle/3990099045/8441
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| Title: | Serum 25-hydroxyvitamin d levels in relation to lung function and exhaled nitric oxide in children |
| Authors: | Yao, TC;Tu, YL;Chang, SW;Tsai, HJ;Gu, PW;Ning, HC;Hua, MC;Liao, SL;Tsai, MH;Chiu, CY;Lai, SH;Yeh, KW;Huang, JL |
| Contributors: | Division of Biostatistics and Bioinformatics |
| Abstract: | Objective To investigate the relationship of vitamin D status with lung function and fraction of exhaled nitric oxide (FeNO) in a population sample of children. Study design A total of 1315 children aged 5-18 years were evaluated using serum 25-hydroxyvitamin D [25(OH)D] levels, spirometry, a single-breath online FeNO measurement, and questionnaires. Results After adjusting for confounders, the mean forced vital capacity was 53.4 mL (SE, 26.5 mL; P =.045), and the mean forced expiratory volume in 1 second was 48.2 mL (SE, 23.6 mL; P =.042) lower for children with insufficient serum 25(OH)D levels (20-29.9 ng/mL) compared with those with sufficient 25(OH)D levels (≥30 ng/mL). The mean difference between children with deficient (<20 ng/mL) and sufficient levels of serum 25(OH)D was 81.9 mL (SE, 26.7 mL; P =.002) for forced vital capacity and 55.2 mL (SE, 23.7 mL; P =.020) for forced expiratory volume in 1 second. There was no significant association between serum 25(OH)D levels and FeNO after adjusting for confounders. Conclusions Our results demonstrate a significant relationship between insufficient serum vitamin D levels and worse lung function in children in the community with a suggested dose-response effect. Our findings also suggest that vitamin D status is not a significant determinant of FeNO in children in the general population. |
| Date: | 2014-12 |
| Relation: | Journal of Pediatrics. 2014 Dec;165(6):1098-1103.e1. |
| Link to: | http://dx.doi.org/10.1016/j.jpeds.2014.08.048 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3476&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000345526500009 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84912075447 |
| Appears in Collections: | [蔡慧如] 期刊論文
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| SCP84912075447.pdf | | 384Kb | Adobe PDF | 399 | View/Open |
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