國家衛生研究院 NHRI:Item 3990099045/8441
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    题名: Serum 25-hydroxyvitamin d levels in relation to lung function and exhaled nitric oxide in children
    作者: Yao, TC;Tu, YL;Chang, SW;Tsai, HJ;Gu, PW;Ning, HC;Hua, MC;Liao, SL;Tsai, MH;Chiu, CY;Lai, SH;Yeh, KW;Huang, JL
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Objective To investigate the relationship of vitamin D status with lung function and fraction of exhaled nitric oxide (FeNO) in a population sample of children. Study design A total of 1315 children aged 5-18 years were evaluated using serum 25-hydroxyvitamin D [25(OH)D] levels, spirometry, a single-breath online FeNO measurement, and questionnaires. Results After adjusting for confounders, the mean forced vital capacity was 53.4 mL (SE, 26.5 mL; P =.045), and the mean forced expiratory volume in 1 second was 48.2 mL (SE, 23.6 mL; P =.042) lower for children with insufficient serum 25(OH)D levels (20-29.9 ng/mL) compared with those with sufficient 25(OH)D levels (≥30 ng/mL). The mean difference between children with deficient (<20 ng/mL) and sufficient levels of serum 25(OH)D was 81.9 mL (SE, 26.7 mL; P =.002) for forced vital capacity and 55.2 mL (SE, 23.7 mL; P =.020) for forced expiratory volume in 1 second. There was no significant association between serum 25(OH)D levels and FeNO after adjusting for confounders. Conclusions Our results demonstrate a significant relationship between insufficient serum vitamin D levels and worse lung function in children in the community with a suggested dose-response effect. Our findings also suggest that vitamin D status is not a significant determinant of FeNO in children in the general population.
    日期: 2014-12
    關聯: Journal of Pediatrics. 2014 Dec;165(6):1098-1103.e1.
    Link to: http://dx.doi.org/10.1016/j.jpeds.2014.08.048
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3476&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000345526500009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84912075447
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