邻近类别 會議論文/會議摘要 [5/9] 类别统计 近3年内发表的文件:5(16.67%) 含全文笔数:30(100.00%) 文件下载次数统计 下载大于0次:30(100.00%) 下载大于100次:28(93.33%) 全文下载总次数:13555(88.06%) 最后更新时间: 2024-12-12 09:00 上传排行 数据加载中..... 下载排行 数据加载中..... 最近上传 DBPR116, a prodrug of BPRMU191, in ... Discovery of a mu-opioid receptor m... Benzo[b]thiophene-2-carboxamides as... Selective and antagonist-dependent ... Discovery and development of a nove... Discovery of BPR1R024, an orally ac... Discovery and synthesis of a pyrimi... BPRDP056, a novel small molecule dr... Comparative study between deep lear... Unique sulfur-aromatic interactions...

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日期	题名	關聯
2024-11	DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration	Journal of Medicinal Chemistry. 2024 Nov 14;67(21):19777-19790.
2024-07-17	Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	Cell Chemical Biology. 2024 Jul 17;Article in Press.
2022-12-05	Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation	European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728.
2022-11	Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone	Bioorganic Chemistry. 2022 Nov;128:Article number 105905.
2022-02-05	Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design	European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
2021-10-14	Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model	Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497.
2021-05-19	Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins	Journal of Medicinal Chemistry. 2021 May 19;64(11):7312-7330.
2021-01	BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy	Translational Oncology. 2021 Jan;14(1):Article number 100897.
2020-10-08	Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery	Scientific Reports. 2020 Oct 8;10:Article number 16771.
2020-04	BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine	Neuropharmacology. 2020 Apr;166:Article number 107678.
2020-02-10	Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors	Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659.
2019-12	Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia	Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
2019-07-11	Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates	Journal of Medicinal Chemistry. 2019 Jul 11;62(13):6047-6062.
2019-04-01	The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone	European Journal of Medicinal Chemistry. 2019 Apr 1;167:312-323.
2018-05-10	Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition	European Journal of Medicinal Chemistry. 2018 May 10;151:533-545.
2018-04	4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy	Bioorganic Chemistry. 2018 Apr;77:600-607.
2017-07	Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors	Journal of Medicinal Chemistry. 2017 Jul;60(13):5599-5612.
2017-06-22	Targeting coronaviral replication and cellular JAK2 mediated dominant NF-kappaB activation for comprehensive and ultimate inhibition of coronaviral activity	Scientific Reports. 2017 Jun 22;7:Article number 4105.
2017-05	1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A novel opioid receptor agonist with less accompanying gastrointestinal dysfunction than morphine	Anesthesiology. 2017 May;126(5):952-966.
2017-01	Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists	European Journal of Medicinal Chemistry. 2017 Jan;126:202-217.
2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	Oncotarget. 2016 Dec;7(52):86239-86256.
2016-04-12	Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK)	Journal of Medicinal Chemistry. 2016 Apr 12;59(8):3906-3919.
2016-01	Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1	Journal of Medicinal Chemistry. 2016 Jan;59 (1):282-293.
2016-01	Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy	Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
2015-12	Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model	European Journal of Medicinal Chemistry. 2015 Dec;106:60-74.

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