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http://ir.nhri.org.tw/handle/3990099045/9983
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| Title: | Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists |
| Authors: | Chen, SR;Ke, YY;Yeh, TK;Lin, SY;Ou, LC;Chen, SC;Chang, WT;Chang, HF;Wu, ZH;Hsieh, CC;Law, PY;Loh, HH;Shih, C;Lai, YK;Yeh, SH;Ueng, SH |
| Contributors: | Institute of Biotechnology and Pharmaceutical Research |
| Abstract: | μ-Opioid receptor (MOR) agonists are analgesics used clinically for the treatment of moderate to severe pain, but their use is associated with severe adverse effects such as respiratory depression, constipation, tolerance, dependence, and rewarding effects. In this study, we identified N-({2-[(4-bromo-2-trifluoromethoxyphenyl)sulfonyl]-1,2,3,4-tetrahydro-1-isoquinolinyl}methyl)cyclohexanecarboxamide (1) as a novel opioid receptor agonist by high-throughput screening. Structural modifications made to 1 to improve potency and blood-brain-barrier (BBB) penetration resulted in compounds 45 and 46. Compound 45 was a potent MOR/KOR (κ-opioid receptor) agonist, and compound 46 was a potent MOR and medium KOR agonist. Both 45 and 46 demonstrated a significant anti-nociceptive effect in a tail-flick test performed in wild type (WT) B6 mice. The ED50 value of 46 was 1.059 mg/kg, and the brain concentrations of 45 and 46 were 7424 and 11696 ng/g, respectively. Accordingly, compounds 45 and 46 are proposed for lead optimization and in vivo disease-related pain studies. |
| Date: | 2017-01 |
| Relation: | European Journal of Medicinal Chemistry. 2017 Jan;126:202-217. |
| Link to: | http://dx.doi.org/10.1016/j.ejmech.2016.09.003 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0223-5234&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000396804600020 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84992549305 |
| Appears in Collections: | [翁紹華] 期刊論文
[葉修華] 期刊論文
[石全(2014-2017)] 期刊論文
[葉燈光] 期刊論文
[林書玉] 期刊論文
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| SDO0223523416307310.pdf.pdf | | 1858Kb | Adobe PDF | 686 | View/Open |
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