國家衛生研究院 NHRI:Item 3990099045/8018
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 856883      線上人數 : 952
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8018


    題名: Dengue 2 virus infection activates autophagy that is favorable for viral replication in mosquito aedes aegypti
    作者: Chen, CC;Tsao, IY;Lu, YC;Shiao, SH;Chen, CH;Tsai, CH
    貢獻者: Institute of Molecular and Genomic Medicine
    摘要: Autophagy is a catabolic process for the maintenance of cellular homeostasis and is also important in times of stress, including viral infection. Recently we found knockdown of three authophagy genes, ATG5, ATG8 and ATG18, significantly reduced the transcriptional levels and tiers of dengue 2 virus(DENV2) in Ades aegypti. We also found that DENV2 transcription level was significantly reduced after autophagy was blocked by 3 methyladenine or L-asparagine and was significantly enhanced after authophagy was induced by rapamycin. Western blotting analysis also demonstrated that level of the LC3-II, the widely used biomarker of authophagy, was significantly increased in DENV2-infected mosquitoes at 24h post inoculatin(p.i.) and reached the maximum at 48h p.i. Then is gradually declined but remained detectable at 96h p.i. Subsequently, our results suggested that in vector mosquitoes, DENV2 can activate autophagy machinery that is favorable for viral replication.
    日期: 2013-12
    關聯: Pathogens and Global Health. 2013 Dec;107(8):404.
    Link to: http://dx.doi.org/10.1179/2047772413Z.000000000160
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2047-7724&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000335056200015
    顯示於類別:[陳俊宏] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000335056200015.pdf111KbAdobe PDF631檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋