國家衛生研究院 NHRI:Item 3990099045/7950
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    題名: CDCA5 overexpression as a poor prognostic factor in patients with urothelial carcinomas of upper urinary tract and urinary bladder
    作者: Chang, IW;Hung, CH;Li, CF
    貢獻者: National Institute of Cancer Research
    摘要: Background: Despite advances in diagnostic imaging and treatment modalities, the risk stratifi cation and fi nal outcomes in patients with urothelial carcinomas (UC) of urinary bladder (UBUC) and upper urinary tract (UTUC) still remain suboptimal. Through data mining from a published transcriptomic database of UBUCs (GSE32894), cell division cycle associated 5 (CDCA5) was identifi ed as the most signifi cant gene showing stepwise upregulation during UBUC progression among those associated with G1-S transition of mitotic cell cycle (GO:0000082). CDCA5 gene encodes Sororin that regulates sister chromatid cohesion and is critical in mitosis. Given the roles of CDCA5 has not been investigated in UC, we therefore analyze its transcript and protein expressions and their associations with clinicopathological factors and survivals in our well-characterized cohort of UC.Design: Quantigene assay was used to detect CDCA5 messenger RNA (mRNA) level in 40 UTUCs and 35 UBUCs, respectively. Immunohistochemistry evaluated by using H-score was used to determine CDCA5 protein expression in 295 UBUCs and 340 UTUCs, respectively. The mRNA and protein expression statuses were further correlated with clinicopathological features. The prognostic signifi cance of CDCA5 protein expression was further evaluated for disease-specifi c survival (DSS) and metastasis-free survival (MeFS).Results: Increment of CDCA5 transcript level was associated with higher pT status and nodal metastasis in both UTUC and UBUC (all p<0.05). CDCA5 protein overexpression was also signifi cantly associated with advanced pT status (both p<0.001), lymph node metastasis (UTUC, p<0.001; UBUC, p=0.033), high histological grade (both p<0.001), vascular invasion (UTUC, p<0.001; UBUC, p=0.045), frequent mitoses (UTUC, p=0.002; UBUC, p<0.001) in both groups of UC. CDCA5 overexpression not only predicted worse DSS and MeFS at univariate analysis, but also implicated inferior DSS (both p=0.016) and MeFS (UTUC, p=0.006; UBUC, p<0.001) in multivariate analysis.Conclusions: CDCA5 overexpression is associated with advanced tumor status and implicated adverse clinical outcome for both patients of UTUC and UBUC. Our study disclosed that CDCA5 plays an important role in tumor progression in UC and may serve as a potential prognostic biomarker and a novel therapeutic target of UC.
    日期: 2014-02
    關聯: Laboratory Investigation. 2014 Feb;94(S1):220A.
    Link to: http://dx.doi.org/10.1038/labinvest.2014.23
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0023-6837&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000331155801118
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