國家衛生研究院 NHRI:Item 3990099045/7950
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 857761      在线人数 : 798
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7950


    题名: CDCA5 overexpression as a poor prognostic factor in patients with urothelial carcinomas of upper urinary tract and urinary bladder
    作者: Chang, IW;Hung, CH;Li, CF
    贡献者: National Institute of Cancer Research
    摘要: Background: Despite advances in diagnostic imaging and treatment modalities, the risk stratifi cation and fi nal outcomes in patients with urothelial carcinomas (UC) of urinary bladder (UBUC) and upper urinary tract (UTUC) still remain suboptimal. Through data mining from a published transcriptomic database of UBUCs (GSE32894), cell division cycle associated 5 (CDCA5) was identifi ed as the most signifi cant gene showing stepwise upregulation during UBUC progression among those associated with G1-S transition of mitotic cell cycle (GO:0000082). CDCA5 gene encodes Sororin that regulates sister chromatid cohesion and is critical in mitosis. Given the roles of CDCA5 has not been investigated in UC, we therefore analyze its transcript and protein expressions and their associations with clinicopathological factors and survivals in our well-characterized cohort of UC.Design: Quantigene assay was used to detect CDCA5 messenger RNA (mRNA) level in 40 UTUCs and 35 UBUCs, respectively. Immunohistochemistry evaluated by using H-score was used to determine CDCA5 protein expression in 295 UBUCs and 340 UTUCs, respectively. The mRNA and protein expression statuses were further correlated with clinicopathological features. The prognostic signifi cance of CDCA5 protein expression was further evaluated for disease-specifi c survival (DSS) and metastasis-free survival (MeFS).Results: Increment of CDCA5 transcript level was associated with higher pT status and nodal metastasis in both UTUC and UBUC (all p<0.05). CDCA5 protein overexpression was also signifi cantly associated with advanced pT status (both p<0.001), lymph node metastasis (UTUC, p<0.001; UBUC, p=0.033), high histological grade (both p<0.001), vascular invasion (UTUC, p<0.001; UBUC, p=0.045), frequent mitoses (UTUC, p=0.002; UBUC, p<0.001) in both groups of UC. CDCA5 overexpression not only predicted worse DSS and MeFS at univariate analysis, but also implicated inferior DSS (both p=0.016) and MeFS (UTUC, p=0.006; UBUC, p<0.001) in multivariate analysis.Conclusions: CDCA5 overexpression is associated with advanced tumor status and implicated adverse clinical outcome for both patients of UTUC and UBUC. Our study disclosed that CDCA5 plays an important role in tumor progression in UC and may serve as a potential prognostic biomarker and a novel therapeutic target of UC.
    日期: 2014-02
    關聯: Laboratory Investigation. 2014 Feb;94(S1):220A.
    Link to: http://dx.doi.org/10.1038/labinvest.2014.23
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0023-6837&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000331155801118
    显示于类别:[其他] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000331155801118.pdf130KbAdobe PDF517检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈