國家衛生研究院 NHRI:Item 3990099045/7418
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    題名: In-situ formation and assembly of gold nanoparticles by gum arabic as efficient photothermal agent for killing cancer cells
    作者: Liu, CP;Lin, FS;Chien, CT;Tseng, SY;Luo, CW;Chen, CH;Chen, JK;Tseng, FG;Hwu, Y;Lo, LW;Yang, CS;Lin, SY
    貢獻者: Center for Nanomedicine Research;Division of Medical Engineering Research
    摘要: Gold nanoparticles (AuNPs) have been established to sufficiently eradicate tumors by means of heat production for photothermal therapy. However, the translation of the AuNPs from bench to the clinic still remains to be solved until realizing high bioclearance after treatment. Herein, we developed a simple strategy for simultaneous formation and assembly of small-size gold nanoparticles (Au-SNPs) to form a novel nanocomposite in the presence of gum arabic (GA) by synchrotron X-ray irradiation in an aqueous solution within 5 min. GA, a porous polysaccharide, can not only provide a confined space in which to produce uniform Au-SNPs (1.6 +/- 0.7 nm in diameter), but can also facilitate the formation of Au-SNPs@GA (diameter approximately 40 nm) after irradiating synchrotron X-rays. Specifically, the Au-SNPs@GA possesses high thermal stability and a strong photothermal effect for killing cancer cells. Importantly, a bioclearance study demonstrated that the Au-SNPs@GA can be gradually excreted by the renal and hepatobiliary system, which might be due to the breakdown and oxidation of GA under irradiating synchrotron X-rays. Thus, the novel gold nanocomposite can be promising photothermal agents for cancer treatment at the therapeutic level, minimizing toxicity concerns regarding long-term accumulation in vivo.
    日期: 2013-10
    關聯: Macromolecular Bioscience. 2013 Oct;131(10):1314-1320.
    Link to: http://dx.doi.org/10.1002/mabi.201300162
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1616-5187&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000328744300004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84885947379
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