國家衛生研究院 NHRI:Item 3990099045/7418
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12189/12972 (94%)
造访人次 : 955583      在线人数 : 763
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7418


    题名: In-situ formation and assembly of gold nanoparticles by gum arabic as efficient photothermal agent for killing cancer cells
    作者: Liu, CP;Lin, FS;Chien, CT;Tseng, SY;Luo, CW;Chen, CH;Chen, JK;Tseng, FG;Hwu, Y;Lo, LW;Yang, CS;Lin, SY
    贡献者: Center for Nanomedicine Research;Division of Medical Engineering Research
    摘要: Gold nanoparticles (AuNPs) have been established to sufficiently eradicate tumors by means of heat production for photothermal therapy. However, the translation of the AuNPs from bench to the clinic still remains to be solved until realizing high bioclearance after treatment. Herein, we developed a simple strategy for simultaneous formation and assembly of small-size gold nanoparticles (Au-SNPs) to form a novel nanocomposite in the presence of gum arabic (GA) by synchrotron X-ray irradiation in an aqueous solution within 5 min. GA, a porous polysaccharide, can not only provide a confined space in which to produce uniform Au-SNPs (1.6 +/- 0.7 nm in diameter), but can also facilitate the formation of Au-SNPs@GA (diameter approximately 40 nm) after irradiating synchrotron X-rays. Specifically, the Au-SNPs@GA possesses high thermal stability and a strong photothermal effect for killing cancer cells. Importantly, a bioclearance study demonstrated that the Au-SNPs@GA can be gradually excreted by the renal and hepatobiliary system, which might be due to the breakdown and oxidation of GA under irradiating synchrotron X-rays. Thus, the novel gold nanocomposite can be promising photothermal agents for cancer treatment at the therapeutic level, minimizing toxicity concerns regarding long-term accumulation in vivo.
    日期: 2013-10
    關聯: Macromolecular Bioscience. 2013 Oct;131(10):1314-1320.
    Link to: http://dx.doi.org/10.1002/mabi.201300162
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1616-5187&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000328744300004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84885947379
    显示于类别:[陳仁焜] 期刊論文
    [林淑宜] 期刊論文
    [羅履維] 期刊論文
    [楊重熙] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB23861238.pdf570KbAdobe PDF640检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈