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生技與藥物研究所
郭靜娟
--期刊論文
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Lysosomal-targeted doxorubicin deli...
How to deal with frenemy NRF2: Targ...
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2023-11
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death
Pharmacological Research. 2023 Nov;197:Article number 106945.
2023-03-28
Synthesis and structure–activity relationship of salvinal derivatives as potent microtubule inhibitors
International Journal of Molecular Sciences. 2023 Mar 28;24(7):Article number 6386.
2023-02-28
How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy
Journal of Food and Drug Analysis. 2023 Feb 28;31(3):387-407.
2023-01
Two new chromones and a new coumarin from the fruit of Cnidium monnieri (L.) Cusson
Natural Product Research. 2023 Jan;37(1):47-55.
2022-02-05
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design
European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
2022-01-17
Pilot study: Nutritional and preclinical safety investigation of fermented hispidin-enriched sanghuangporus sanghuang mycelia: A promising functional food material to improve sleep
Frontiers in Nutrition. 2022 Jan 17;8:Article number 788965.
2021-12-14
A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells
Journal of Food and Drug Analysis. 2021 Dec 14;29(4):638-652.
2021-10-29
Type-3 hyaluronan synthase attenuates tumor cells invasion in human mammary parenchymal tissues
Molecules. 2021 Oct 29;26(21):Article number 6548.
2021-08-12
Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2)
Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301.
2021-03-15
Tea polyphenol epigallocatechin-3-gallate inhibits cell proliferation in a patient-derived triple-negative breast cancer xenograft mouse model via inhibition of proline-dehydrogenase-induced effects
Journal of Food and Drug Analysis. 2021 Mar 15;29(1):113-127.
2021-03-11
c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation
Theranostics. 2021 Mar 11;11(11):5232-5247.
2020-08
Two new diprenylated flavanones from Derris laxiflora Benth
Natural Product Research. 2020 Aug;34(15):2101-2108.
2020-04-02
MiR-30a and miR-379 modulate retinoic acid pathway by targeting DNA methyltransferase 3B in oral cancer
Journal of Biomedical Science. 2020 Apr 2;27:Article number 46.
2020-02-10
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors
Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659.
2019-12-24
ERK activation modulates cancer stemness and motility of a novel mouse oral squamous cell carcinoma cell line
Cancers. 2019 Dec 24;12(1):Article number 61.
2019-12
Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia
Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
2019-08
Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3-induced mitophagy
Cancer Medicine. 2019 Aug;8(10):4821-4835.
2018-12
Ubiquitin-conjugating enzyme E2 B regulates the ubiquitination of O(6)-methylguanine-DNA methyltransferase and BCNU sensitivity in human nasopharyngeal carcinoma cells
Biochemical Pharmacology. 2018 Dec;158:327-338.
2018-06-15
2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition [Erratum: Organic and Biomolecular Chemistry. 2016 Jan;14(2):716-723.]
Organic and biomolecular chemistry. 2018 Jun 15;16:4734.
2018-04
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy
Bioorganic Chemistry. 2018 Apr;77:600-607.
2017-12
Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells
Free Radical Biology and Medicine. 2017 Dec;113:505-518.
2017-08
Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness
Cancer Research. 2017 Aug;77(16):4305-4316.
2017-07
Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors
Journal of Biomolecular Structure and Dynamics. 2017 Jun;35(8):1833-1848.
2017-07
Design, synthesis, and evaluation of thiazolidine-2,4-dione derivatives as a novel class of glutaminase inhibitors
Journal of Medicinal Chemistry. 2017 Jul;60(13):5599-5612.
2016-12
Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation
Oncotarget. 2016 Dec;7(52):86239-86256.
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