國家衛生研究院 NHRI:Item 3990099045/7026
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 857929      線上人數 : 588
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/7026


    題名: Impact of initial vascular permeability and recovery speed of disrupted Blood-Brain Barrier on nanodrug delivery into the brain tissue
    作者: Lu, KW;Wu, HY;Huang, CK;Horng, TL;Chou, CY;Lin, WL
    貢獻者: Division of Medical Engineering Research
    摘要: Delivery of drugs across Blood-brain barrier (BBB) can be enhanced by physical stimulation (e.g. ultrasound). When BBB is opened by ultrasound sonication in the presence of microbubbles, its vascular permeability will decay due to BBB repairing. The transport and accumulation of nanodrugs in brain tissue is affected by both physicochemical properties of drugs and closure dynamics of BBB. In this study, we developed a mathematical model and employed animal experiments to investigate the impact of recovery of disrupted BBB on nanodrug delivery into brain tissue. We chose Evans blue (EB)-albumin complexes as a model nanodrug and studied the effects of initial permeability, decaying speed of permeability and half-life of EB-albumin complexes on their spatial-temporal concentration response and accumulation in brain tissue. The transport parameters used in this model were obtained from previously published studies and the fitting of our experimental data with Particle Swarm Optimization (PSO). The simulation results showed that there exists optimal initial permeability and decaying speed of permeability to achieve a maximum AUC (area under the concentration-time curve) of EB-albumin in the brain tissue. The results indicate that we can enhance the accumulation of nanodrugs safely in brain tissue by controlling the recovery dynamics of BBB opening.
    日期: 2013-01-29
    關聯: Biophysical Journal. 2013 Jan 29;104(2, Suppl. 1):688a.
    Link to: http://dx.doi.org/10.1016/j.bpj.2012.11.3801
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-3495&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000316074306485
    顯示於類別:[其他] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SDO0006349512050473.pdf37KbAdobe PDF500檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋