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显示项目51-73 / 73. (共3页) << < 1 2 3  每页显示[10|25|50]项目

日期	题名	關聯
2010-02	Alpha-activated cross conjugated cycloalkenone systems in organic synthesis	Current Organic Synthesis. 2010 Feb;7(1):78-93.
2009-07-23	Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice	Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4496-4510.
2009-04-16	Polyene cyclization promoted by the cross-conjugated alpha-carbalkoxy cyclohexenone system. An unusual 1,2-hydride shift under lewis acid catalysis	Organic Letters. 2009 Apr 16;11(8):1673-1675.
2009	A concise total synthesis of (±)-acutifolone A	Organic and Biomolecular Chemistry. 2009;7(16):3285-3290.
2008-09-21	Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists	Organic and Biomolecular Chemistry. 2008 Sep 21;6(18):3399-3407.
2008-09-11	Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists	Journal of Medicinal Chemistry. 2008 Sep 11;51(17):5397-5412.
2008-02-07	Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists	Organic and Biomolecular Chemistry. 2008 Feb;6(3):447-450.
2008-01-03	Polyene cyclization promoted by the cross-conjugated alpha-carbalkoxy enone system. Observation on a putative 1,5-hydride/1,3-alkyl shift under Lewis acid catalysis	Organic Letters. 2008 Jan;10(1):121-123.
2007-05-16	Lithium naphthalenide induced reductive selenenylation of alpha-cyano ketones: A regiocontrolled process for alpha-phenylseleno ketones and one-pot conversion into enone system	Synlett. 2007 May(8):1274-1278.
2007-05-16	An efficient new procedure for the one-pot conversion of aldehydes into the corresponding nitriles	Synlett. 2007 May(8):1317-1319.
2007	A convenient new procedure for converting primary amides into nitriles	Chemical Communications. 2007 (3):301-303.
2005-04	Carbapenern-based prodrugs. Design, synthesis, and biological evaluation of carbapenems	European Journal of Medicinal Chemistry. 2005 Apr;40(4):339-349.
2005	Design, synthesis and biological evaluation of novel carbapenems	International Journal of Scientific Research. 2005;14:59-70
2004-10-18	Synthesis and antienteroviral activity of a series of novel, oxime ether-containing pyridyl imidazolidinones	Bioorganic and Medicinal Chemistry Letters. 2004 Oct;14(20):5051-5056.
2004-09	Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone	Antimicrobial Agents and Chemotherapy. 2004 Sep;48(9):3523-3529.
2004-05-17	Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidinies: a novel class of potent enterovirus inhibitors	Bioorganic and Medicinal Chemistry Letters. 2004 May;14(10):2519-2525.
2004-03-08	Synthesis and in vitro cytotoxicity of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives	Bioorganic and Medicinal Chemistry Letters. 2004 Mar;14(5):1169-1172.
2003-02-17	A modified Robinson annulation process to alpha,alpha-disubstituted-beta,gamma-unsaturated cyclohexanone system. Application to the total synthesis of nanaimoal	Tetrahedron. 2003 Feb;59(8):1209-1226.
2002-10-07	Synthesis and anticancer evaluation of vitamin K-3 analogues	Bioorganic and Medicinal Chemistry Letters. 2002 Oct;12(19):2729-2732.
2002-04-11	Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: A novel class of potent and selective human enterovirus 71 inhibitors	Journal of Medicinal Chemistry. 2002 Apr;45(8):1644-1655.
2002	Diels-Alder chemistry of 2-diethoxyphosphinylcyclohex-2-enones. A new approach to complex phosphonates and synthetic applications of the beta-keto phosphonate system	Chemical Communications. 2002(3):248-249.
2001-11	An efficacious synthetic strategy for cis-clerodane diterpenoids. Application to the total synthesis of (+/-)-6 beta-acetoxy-2-oxokolavenool	Synlett. 2001 Nov(11):1805-1807.
1999-06	Polyene cyclization promoted by the cross conjugated alpha-carbalkoxy enone system. An efficient approach to highly functionalized decalins	Journal of the Chinese Chemical Society. 1999 Jun;46(3):453-462.

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