國家衛生研究院 NHRI:Item 3990099045/6562
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    题名: Quantitative characterization of nanoparticles in blood by transmission electron microscopy with a window-type microchip nanopipet
    作者: Tai, LA;Kang, YT;Chen, YC;Wang, YC;Wang, YJ;Wu, YT;Liu, KL;Wang, CY;Ko, YF;Chen, CY;Huang, NC;Chen, JK;Hsieh, YF;Yew, TR;Yang, CS
    贡献者: Center for Nanomedicine Research
    摘要: Transmission electron microscopy (TEM) is a unique and powerful tool for observation of nanoparticles. However, due to the uneven spatial distribution of particles conventionally dried on copper grids, TEM is rarely employed to evaluate the spatial distribution of nanoparticles in aqueous solutions. Here, we present a microchip nanopipet with a narrow chamber width for sorting nanoparticles from blood and preventing the aggregation of the particles during the drying process, enabling quantitative analysis of their aggregation/agglomeration states and the particle concentration in aqueous solutions. This microchip is adaptable to all commercial TEM holders. Such a nanopipet proves to be a simple and convenient sampling device for TEM image-based quantitative characterization.
    日期: 2012-08
    關聯: Analytical Chemistry. 2012 Aug;84(15):6312-6316.
    Link to: http://dx.doi.org/10.1021/ac301523n
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0003-2700&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000307159200008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864632177
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