國家衛生研究院 NHRI:Item 3990099045/6562

NHRI > Institute of Biomedical Engineering and Nanomedicine > Chung-Shi Yang > Periodical Articles > Item 3990099045/6562

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6562

Title:	Quantitative characterization of nanoparticles in blood by transmission electron microscopy with a window-type microchip nanopipet
Authors:	Tai, LA;Kang, YT;Chen, YC;Wang, YC;Wang, YJ;Wu, YT;Liu, KL;Wang, CY;Ko, YF;Chen, CY;Huang, NC;Chen, JK;Hsieh, YF;Yew, TR;Yang, CS
Contributors:	Center for Nanomedicine Research
Abstract:	Transmission electron microscopy (TEM) is a unique and powerful tool for observation of nanoparticles. However, due to the uneven spatial distribution of particles conventionally dried on copper grids, TEM is rarely employed to evaluate the spatial distribution of nanoparticles in aqueous solutions. Here, we present a microchip nanopipet with a narrow chamber width for sorting nanoparticles from blood and preventing the aggregation of the particles during the drying process, enabling quantitative analysis of their aggregation/agglomeration states and the particle concentration in aqueous solutions. This microchip is adaptable to all commercial TEM holders. Such a nanopipet proves to be a simple and convenient sampling device for TEM image-based quantitative characterization.
Date:	2012-08
Relation:	Analytical Chemistry. 2012 Aug;84(15):6312-6316.
Link to:	http://dx.doi.org/10.1021/ac301523n
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0003-2700&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000307159200008
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864632177
Appears in Collections:	[Chung-Shi Yang] Periodical Articles [Jen-Kun Chen] Periodical Articles

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