國家衛生研究院 NHRI:Item 3990099045/6302
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 855642      線上人數 : 1281
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/6302


    題名: Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients
    作者: Wang, SC;Tsou, HH;Chen, CH;Chen, YT;Ho, IK;Hsiao, CF;Chou, SY;Lin, YF;Fang, KC;Huang, CL;Su, LW;Fang, YC;Liu, ML;Wu, HY;Lin, KM;Liu, SC;Kuo, HW;Chiang, IC;Chen, AC;Tian, JN;Liu, YL
    貢獻者: Division of Mental Health and Addiction Medicine;Division of Biostatistics and Bioinformatics;Division of Clinical Trial Statistics
    摘要: Methadone, a synthetic racemic opioid that primarily works as a mu-opioid receptor (OPRM1) agonist, is commonly used for the treatment of heroin addiction. Genetic association studies have reported that the OPRM1 gene is involved in the physiology of heroin and alcohol addiction. Our current study is designed to test the hypothesis that genetic polymorphisms in the OPRM1 gene region are associated with methadone dosage, plasma concentrations, treatment responses, adverse reactions and withdrawal symptoms in a methadone maintenance treatment (MMT) cohort from Taiwan. Fifteen OPRM1 single nucleotide polymorphisms (SNPs) were selected and genotyped using DNA samples from 366 MMT patients. The plasma concentrations of methadone and its metabolite were measured by high performance liquid chromatography. The results obtained using dominant model analysis indicate that the OPRM1 SNPs rs1074287, rs6912029, rs12209447, rs510769, rs3798676, rs7748401, rs495491, rs10457090, rs589046, rs3778152, rs563649, and rs2075572 are significantly associated with change-in-libido side effects (adjusted p<0.042). Using recessive model analysis, these SNPs were also found to be significantly associated with insomnia side effects in this cohort (p<0.009). The significance of the insomnia findings was mainly contributed by a subgroup of patients who had a positive urine morphine test (p<0.022), and by individuals who did not use benzodiazepine hypnotics (p<0.034). Our current data thus suggest that genetic polymorphisms in OPRM1 may influence the change-in-libido and insomnia side effects sometimes found in MMT patients.
    日期: 2012-10
    關聯: European Neuropsychopharmacology. 2012 Oct;22(10):695-703.
    Link to: http://dx.doi.org/10.1016/j.euroneuro.2012.02.002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-977X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000309781200002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84865565339
    顯示於類別:[王聲昌] 期刊論文
    [鄒小蕙] 期刊論文
    [何英剛(2006-2011)] 期刊論文
    [蕭金福] 期刊論文
    [林克明(2004-2009)] 期刊論文
    [劉玉麗] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB22406240.pdf385KbAdobe PDF723檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋