國家衛生研究院 NHRI:Item 3990099045/6302
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/6302


    Title: Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients
    Authors: Wang, SC;Tsou, HH;Chen, CH;Chen, YT;Ho, IK;Hsiao, CF;Chou, SY;Lin, YF;Fang, KC;Huang, CL;Su, LW;Fang, YC;Liu, ML;Wu, HY;Lin, KM;Liu, SC;Kuo, HW;Chiang, IC;Chen, AC;Tian, JN;Liu, YL
    Contributors: Division of Mental Health and Addiction Medicine;Division of Biostatistics and Bioinformatics;Division of Clinical Trial Statistics
    Abstract: Methadone, a synthetic racemic opioid that primarily works as a mu-opioid receptor (OPRM1) agonist, is commonly used for the treatment of heroin addiction. Genetic association studies have reported that the OPRM1 gene is involved in the physiology of heroin and alcohol addiction. Our current study is designed to test the hypothesis that genetic polymorphisms in the OPRM1 gene region are associated with methadone dosage, plasma concentrations, treatment responses, adverse reactions and withdrawal symptoms in a methadone maintenance treatment (MMT) cohort from Taiwan. Fifteen OPRM1 single nucleotide polymorphisms (SNPs) were selected and genotyped using DNA samples from 366 MMT patients. The plasma concentrations of methadone and its metabolite were measured by high performance liquid chromatography. The results obtained using dominant model analysis indicate that the OPRM1 SNPs rs1074287, rs6912029, rs12209447, rs510769, rs3798676, rs7748401, rs495491, rs10457090, rs589046, rs3778152, rs563649, and rs2075572 are significantly associated with change-in-libido side effects (adjusted p<0.042). Using recessive model analysis, these SNPs were also found to be significantly associated with insomnia side effects in this cohort (p<0.009). The significance of the insomnia findings was mainly contributed by a subgroup of patients who had a positive urine morphine test (p<0.022), and by individuals who did not use benzodiazepine hypnotics (p<0.034). Our current data thus suggest that genetic polymorphisms in OPRM1 may influence the change-in-libido and insomnia side effects sometimes found in MMT patients.
    Date: 2012-10
    Relation: European Neuropsychopharmacology. 2012 Oct;22(10):695-703.
    Link to: http://dx.doi.org/10.1016/j.euroneuro.2012.02.002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-977X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000309781200002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84865565339
    Appears in Collections:[Sheng-Chang Wang] Periodical Articles
    [Hsiao-Hui Sophie Tsou] Periodical Articles
    [Ing-Kang Ho(2006-2011)] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles
    [Keh-Ming Lin(2004-2009)] Periodical Articles
    [Yu-Li Liu] Periodical Articles

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