國家衛生研究院 NHRI:Item 3990099045/5504
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    題名: Isatin-beta-thiosemicarbazones as potent herpes simplex virus inhibitors
    其他題名: Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors
    作者: Kang, IJ;Wang, LW;Hsu, TA;Yueh, A;Lee, CC;Lee, YC;Lee, CY;Chao, YS;Shih, SR;Chern, JH
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: A series of isatin-beta-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-beta-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their anti-herpetic activity. The synthesis and structure-activity relationship studies are presented.
    日期: 2011-04
    關聯: Bioorganic and Medicinal Chemistry Letters. 2011 Apr;21(7):1948-1952.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2011.02.037
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000288245100008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952484386
    顯示於類別:[徐祖安] 期刊論文
    [陳志豪] 期刊論文
    [岳嶽] 期刊論文
    [趙宇生(2002-2013)] 期刊論文

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